Cardiac Stem Cells in Patients with Ischemic Cardiomyopathy: Discovery, Translation, and Clinical Investigation

The increasing prevalence of heart failure, in the US and worldwide, poses a significant burden to patients, practitioners, and healthcare systems. Hence, there is a pressing need for alternative therapies to enhance the current treatment armamentarium. Accordingly, when considering heart failure of...

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Published in:Current atherosclerosis reports Vol. 14; no. 5; pp. 491 - 503
Main Authors: Loughran, John H., Elmore, Julius B., Waqar, Momina, Chugh, Atul R., Bolli, Roberto
Format: Journal Article
Language:English
Published: New York Current Science Inc 01-10-2012
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Abstract The increasing prevalence of heart failure, in the US and worldwide, poses a significant burden to patients, practitioners, and healthcare systems. Hence, there is a pressing need for alternative therapies to enhance the current treatment armamentarium. Accordingly, when considering heart failure of ischemic etiology, an intervention designed to regenerate the attending loss of myocardium could potentially result in improved cardiac function, functional status, and quality of life. Significant strides have been made by investigators in the study of stem cell therapy for cardiac repair; recently with cardiac-derived progenitor cells. These cells include cardiospheres, cardiosphere-derived cells, and c-kit positive cardiac stem cells. Herein, a review of both preclinical studies and phase I clinical trials of these cell types is presented. A detailed account of in vitro characterization, in vivo bioactivity, and safety and efficacy in humans is outlined. Thus far, encouraging results have been realized, although larger studies have yet to be undertaken.
AbstractList The increasing prevalence of heart failure, in the US and worldwide, poses a significant burden to patients, practitioners, and healthcare systems. Hence, there is a pressing need for alternative therapies to enhance the current treatment armamentarium. Accordingly, when considering heart failure of ischemic etiology, an intervention designed to regenerate the attending loss of myocardium could potentially result in improved cardiac function, functional status, and quality of life. Significant strides have been made by investigators in the study of stem cell therapy for cardiac repair; recently with cardiac-derived progenitor cells. These cells include cardiospheres, cardiosphere-derived cells, and c-kit positive cardiac stem cells. Herein, a review of both preclinical studies and phase I clinical trials of these cell types is presented. A detailed account of in vitro characterization, in vivo bioactivity, and safety and efficacy in humans is outlined. Thus far, encouraging results have been realized, although larger studies have yet to be undertaken.
The increasing prevalence of heart failure, in the US and worldwide, poses a significant burden to patients, practitioners, and healthcare systems. Hence, there is a pressing need for alternative therapies to enhance the current treatment armamentarium. Accordingly, when considering heart failure of ischemic etiology, an intervention designed to regenerate the attending loss of myocardium could potentially result in improved cardiac function, functional status, and quality of life. Significant strides have been made by investigators in the study of stem cell therapy for cardiac repair; recently with cardiac-derived progenitor cells. These cells include cardiospheres, cardiosphere-derived cells, and c-kit positive cardiac stem cells. Herein, a review of both preclinical studies and phase I clinical trials of these cell types is presented. A detailed account of in vitro characterization, in vivo bioactivity, and safety and efficacy in humans is outlined. Thus far, encouraging results have been realized, although larger studies have yet to be undertaken.
Author Loughran, John H.
Waqar, Momina
Elmore, Julius B.
Bolli, Roberto
Chugh, Atul R.
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  givenname: Julius B.
  surname: Elmore
  fullname: Elmore, Julius B.
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  givenname: Atul R.
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  organization: Division of Cardiovascular Medicine, University of Louisville
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  givenname: Roberto
  surname: Bolli
  fullname: Bolli, Roberto
  organization: Division of Cardiovascular Medicine, University of Louisville
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Snippet The increasing prevalence of heart failure, in the US and worldwide, poses a significant burden to patients, practitioners, and healthcare systems. Hence,...
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SubjectTerms Angiology
Animals
Cardiology
Cardiomyopathies - metabolism
Cardiomyopathies - therapy
Cell- and Tissue-Based Therapy
Clinical Trials and Their Interpretations (J Plutzky
Humans
Medicine
Medicine & Public Health
Myocardial Ischemia - metabolism
Myocardial Ischemia - therapy
Myocytes, Cardiac - cytology
Myocytes, Cardiac - metabolism
Section Editor
Stem Cell Transplantation - methods
Stem Cells - cytology
Stem Cells - metabolism
Title Cardiac Stem Cells in Patients with Ischemic Cardiomyopathy: Discovery, Translation, and Clinical Investigation
URI https://link.springer.com/article/10.1007/s11883-012-0273-9
https://www.ncbi.nlm.nih.gov/pubmed/22847771
https://search.proquest.com/docview/1038596831
Volume 14
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