Cardiac Stem Cells in Patients with Ischemic Cardiomyopathy: Discovery, Translation, and Clinical Investigation
The increasing prevalence of heart failure, in the US and worldwide, poses a significant burden to patients, practitioners, and healthcare systems. Hence, there is a pressing need for alternative therapies to enhance the current treatment armamentarium. Accordingly, when considering heart failure of...
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Published in: | Current atherosclerosis reports Vol. 14; no. 5; pp. 491 - 503 |
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01-10-2012
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Abstract | The increasing prevalence of heart failure, in the US and worldwide, poses a significant burden to patients, practitioners, and healthcare systems. Hence, there is a pressing need for alternative therapies to enhance the current treatment armamentarium. Accordingly, when considering heart failure of ischemic etiology, an intervention designed to regenerate the attending loss of myocardium could potentially result in improved cardiac function, functional status, and quality of life. Significant strides have been made by investigators in the study of stem cell therapy for cardiac repair; recently with cardiac-derived progenitor cells. These cells include cardiospheres, cardiosphere-derived cells, and c-kit positive cardiac stem cells. Herein, a review of both preclinical studies and phase I clinical trials of these cell types is presented. A detailed account of
in vitro
characterization,
in vivo
bioactivity, and safety and efficacy in humans is outlined. Thus far, encouraging results have been realized, although larger studies have yet to be undertaken. |
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AbstractList | The increasing prevalence of heart failure, in the US and worldwide, poses a significant burden to patients, practitioners, and healthcare systems. Hence, there is a pressing need for alternative therapies to enhance the current treatment armamentarium. Accordingly, when considering heart failure of ischemic etiology, an intervention designed to regenerate the attending loss of myocardium could potentially result in improved cardiac function, functional status, and quality of life. Significant strides have been made by investigators in the study of stem cell therapy for cardiac repair; recently with cardiac-derived progenitor cells. These cells include cardiospheres, cardiosphere-derived cells, and c-kit positive cardiac stem cells. Herein, a review of both preclinical studies and phase I clinical trials of these cell types is presented. A detailed account of in vitro characterization, in vivo bioactivity, and safety and efficacy in humans is outlined. Thus far, encouraging results have been realized, although larger studies have yet to be undertaken. The increasing prevalence of heart failure, in the US and worldwide, poses a significant burden to patients, practitioners, and healthcare systems. Hence, there is a pressing need for alternative therapies to enhance the current treatment armamentarium. Accordingly, when considering heart failure of ischemic etiology, an intervention designed to regenerate the attending loss of myocardium could potentially result in improved cardiac function, functional status, and quality of life. Significant strides have been made by investigators in the study of stem cell therapy for cardiac repair; recently with cardiac-derived progenitor cells. These cells include cardiospheres, cardiosphere-derived cells, and c-kit positive cardiac stem cells. Herein, a review of both preclinical studies and phase I clinical trials of these cell types is presented. A detailed account of in vitro characterization, in vivo bioactivity, and safety and efficacy in humans is outlined. Thus far, encouraging results have been realized, although larger studies have yet to be undertaken. |
Author | Loughran, John H. Waqar, Momina Elmore, Julius B. Bolli, Roberto Chugh, Atul R. |
Author_xml | – sequence: 1 givenname: John H. surname: Loughran fullname: Loughran, John H. email: Jhloug01@louisville.edu organization: Division of Cardiovascular Medicine, University of Louisville – sequence: 2 givenname: Julius B. surname: Elmore fullname: Elmore, Julius B. organization: Division of Cardiovascular Medicine, University of Louisville – sequence: 3 givenname: Momina surname: Waqar fullname: Waqar, Momina organization: Dow Medical College, Dow University of Health Sciences – sequence: 4 givenname: Atul R. surname: Chugh fullname: Chugh, Atul R. organization: Division of Cardiovascular Medicine, University of Louisville – sequence: 5 givenname: Roberto surname: Bolli fullname: Bolli, Roberto organization: Division of Cardiovascular Medicine, University of Louisville |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22847771$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1371_journal_pone_0109325 crossref_primary_10_3390_cells7090114 crossref_primary_10_1089_ten_teb_2016_0136 crossref_primary_10_5301_jabfm_5000255 crossref_primary_10_7759_cureus_41533 crossref_primary_10_33529_ANGIO2019414 crossref_primary_10_1161_CIRCRESAHA_113_302564 crossref_primary_10_1155_2015_135023 crossref_primary_10_1161_CIRCRESAHA_116_309731 |
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Keywords | Cardiac stem cells Stem cell therapy Chronic ischemic heart disease Myogenesis CAD |
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SubjectTerms | Angiology Animals Cardiology Cardiomyopathies - metabolism Cardiomyopathies - therapy Cell- and Tissue-Based Therapy Clinical Trials and Their Interpretations (J Plutzky Humans Medicine Medicine & Public Health Myocardial Ischemia - metabolism Myocardial Ischemia - therapy Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Section Editor Stem Cell Transplantation - methods Stem Cells - cytology Stem Cells - metabolism |
Title | Cardiac Stem Cells in Patients with Ischemic Cardiomyopathy: Discovery, Translation, and Clinical Investigation |
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