SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY EVALUATION OF SOME ACRIDINYL AMINO ANTIPYRINE, ACRIDINYL AMINO ANTHRAQUINONE, ACRIDINO THIOUREA AND THIAZOLINO THIOUREA DERIVATIVES

• Published in: Phosphorus, sulfur, and silicon and the related elements Vol. 156; no. 1; pp. 21 - 33
• Main Authors: Sondhi, S. M., Sharma, Vinay K., Singhal, Nidhi, Verma, R. P., Shukla, R., Raghubir, R., Dubey, M. P.
• Format: Journal Article
• Language: English
• Published: Taylor & Francis Group 01-01-2000
• Subjects: acridino thiourea; Acridinyl derivatives; antiinflammatory activity; HRMS; NMR; thiazolino thiourea
• ISSN: 1042-6507; 1563-5325
• DOI: 10.1080/10426500008044991

9- Chloro - 2(substituted) - acridines (I) on condensation with 4 - amino antipyrine, I-amino anthraquinone and 2 - amino anthraquinone gave corresponding condensed products II, III and IV. Phenyl isothiocyanate reacts with 9 - amino - 2 or 4 (substituted)-acridines (V) and iminothiazolines (VII) to give corresponding N-phenyl -N′- substituted thioureas VI and VIII in good yield. Anti-inflammatory activity screening for IIa, b, In, IV, VIb and VIIIa - I was carried out at 100 mg/kg p.o. and compounds IV, VIIIa, VIIIb and VIIIg-k showed 12, 12, 14, 18, 7, 23, 13 and 18% activity whereas all others were found to be inactive. Analgesic activity screening for IIb, III and IV was carried out at 100mg/kg p.o. Only compound III showed 25% activity whereas IIb and IV were found to be inactive.