Tetralone Esters as Intermediates for the Synthesis of Podophyllotoxin Derivatives Via Cyclopropanation of Chalcones

Tetralone Esters as Intermediates for the Synthesis of Podophyllotoxin Derivatives Via Cyclopropanation of Chalcones

Cyclopropyl ester (8a-f) were synthesized by the cyclopropanation of chalcones (7a-e) in dry benzene using powdered sodium in 80-85% yield. Preparation of tetralone ester (4a-e), an intermediate for the synthesis of podophyllotoxin derivatives by Lewis acid (SnCl 4 ) catalyzed cyclization of (8a-e)...

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Bibliographic Details
Published in:Synthetic communications Vol. 30; no. 7; pp. 1179 - 1191
Main Authors: Nanjundaswamy, N., Shashikanth, S., Anjanamurthy, C., Lokanatha Rai, K. M.
Format: Journal Article
Language:English
Published: Taylor & Francis Group 01-04-2000
Online Access:Get full text
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Summary:Cyclopropyl ester (8a-f) were synthesized by the cyclopropanation of chalcones (7a-e) in dry benzene using powdered sodium in 80-85% yield. Preparation of tetralone ester (4a-e), an intermediate for the synthesis of podophyllotoxin derivatives by Lewis acid (SnCl 4 ) catalyzed cyclization of (8a-e) is also described here.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910008087138