Expression of ABCA1 Transporter and LXRA/LXRB Receptors in Placenta of Women with Late Onset Preeclampsia
Background: Appropriate levels of cholesterol are necessary for the mother and developing fetus, but theirexcess may cause preeclampsia. The ABCA1 transporter mediates the secretion of cholesterol and is highly regulated at the transcriptional level via the nuclear liver X receptors (LXRs). Methods:...
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| Published in: | Journal of clinical medicine Vol. 11; no. 16; p. 4809 |
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| Main Authors: | , , , , , , , , , , , , |
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| Abstract | Background: Appropriate levels of cholesterol are necessary for the mother and developing fetus, but theirexcess may cause preeclampsia. The ABCA1 transporter mediates the secretion of cholesterol and is highly regulated at the transcriptional level via the nuclear liver X receptors (LXRs). Methods: Sixteen preeclamptic and 39 normotensives healthy women with uncomplicated pregnancies were involved in the case-control study. The placental levels of ABCA1, LXRA and LXRB mRNA were quantified by real-time quantitative PCR. The concentrations of ABCA1, LXRA and LXRB proteins from the placenta were determined using an enzyme-linked immunosorbent assay Results: We found in the logistic regression model significantly lower placental expression of LXRB mRNA (crude OR = 0.26, 95% CI: 0.07–0.94, p = 0.040) and LXRA protein level (crude OR = 0.19, 95% CI: 0.05–0.69, p = 0.012) in late-onset preeclamptic women compared to healthy pregnant women. The values remained statistically significant after adjustment for possible confounders. Conclusions: Our results suggest that high placenta LXRA mRNA and LXRA protein expression levels decrease the risk of late-onset preeclampsia. These nuclear receptors could play a role in the development of preeclampsia through disturbances of lipid metabolism. |
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| AbstractList | BACKGROUNDAppropriate levels of cholesterol are necessary for the mother and developing fetus, but theirexcess may cause preeclampsia. The ABCA1 transporter mediates the secretion of cholesterol and is highly regulated at the transcriptional level via the nuclear liver X receptors (LXRs). METHODSSixteen preeclamptic and 39 normotensives healthy women with uncomplicated pregnancies were involved in the case-control study. The placental levels of ABCA1, LXRA and LXRB mRNA were quantified by real-time quantitative PCR. The concentrations of ABCA1, LXRA and LXRB proteins from the placenta were determined using an enzyme-linked immunosorbent assay Results: We found in the logistic regression model significantly lower placental expression of LXRB mRNA (crude OR = 0.26, 95% CI: 0.07-0.94, p = 0.040) and LXRA protein level (crude OR = 0.19, 95% CI: 0.05-0.69, p = 0.012) in late-onset preeclamptic women compared to healthy pregnant women. The values remained statistically significant after adjustment for possible confounders. CONCLUSIONSOur results suggest that high placenta LXRA mRNA and LXRA protein expression levels decrease the risk of late-onset preeclampsia. These nuclear receptors could play a role in the development of preeclampsia through disturbances of lipid metabolism. Background: Appropriate levels of cholesterol are necessary for the mother and developing fetus, but theirexcess may cause preeclampsia. The ABCA1 transporter mediates the secretion of cholesterol and is highly regulated at the transcriptional level via the nuclear liver X receptors (LXRs). Methods: Sixteen preeclamptic and 39 normotensives healthy women with uncomplicated pregnancies were involved in the case-control study. The placental levels of ABCA1, LXRA and LXRB mRNA were quantified by real-time quantitative PCR. The concentrations of ABCA1, LXRA and LXRB proteins from the placenta were determined using an enzyme-linked immunosorbent assay Results: We found in the logistic regression model significantly lower placental expression of LXRB mRNA (crude OR = 0.26, 95% CI: 0.07–0.94, p = 0.040) and LXRA protein level (crude OR = 0.19, 95% CI: 0.05–0.69, p = 0.012) in late-onset preeclamptic women compared to healthy pregnant women. The values remained statistically significant after adjustment for possible confounders. Conclusions: Our results suggest that high placenta LXRA mRNA and LXRA protein expression levels decrease the risk of late-onset preeclampsia. These nuclear receptors could play a role in the development of preeclampsia through disturbances of lipid metabolism. Background: Appropriate levels of cholesterol are necessary for the mother and developing fetus, but theirexcess may cause preeclampsia. The ABCA1 transporter mediates the secretion of cholesterol and is highly regulated at the transcriptional level via the nuclear liver X receptors (LXRs). Methods: Sixteen preeclamptic and 39 normotensives healthy women with uncomplicated pregnancies were involved in the case-control study. The placental levels of ABCA1, LXRA and LXRB mRNA were quantified by real-time quantitative PCR. The concentrations of ABCA1, LXRA and LXRB proteins from the placenta were determined using an enzyme-linked immunosorbent assay Results: We found in the logistic regression model significantly lower placental expression of LXRB mRNA (crude OR = 0.26, 95% CI: 0.07–0.94, p = 0.040) and LXRA protein level (crude OR = 0.19, 95% CI: 0.05–0.69, p = 0.012) in late-onset preeclamptic women compared to healthy pregnant women. The values remained statistically significant after adjustment for possible confounders. Conclusions: Our results suggest that high placenta LXRA mRNA and LXRA protein expression levels decrease the risk of late-onset preeclampsia. These nuclear receptors could play a role in the development of preeclampsia through disturbances of lipid metabolism. |
| Author | Kujawski, Radosław Ożarowski, Marcin Czerny, Bogusław Bogacz, Anna Kurzawińska, Grażyna Wolek, Marlena Karpiński, Tomasz M Seremak-Mrozikiewicz, Agnieszka Drews, Krzysztof Mikołajczak, Przemysław Ł Mrozikiewicz, Aleksandra E Łuszczyńska, Małgorzata Wolski, Hubert |
| AuthorAffiliation | 3 Department of Biotechnology, Institute of Natural Fibres and Medicinal Plants, 60-630 Poznan, Poland 2 Division of Obstetrics and Gynecology, Poviat Hospital, 34-500 Zakopane, Poland 8 Department of General Pharmacology and Pharmacoeconomics, Pomeranian Medical University, 70-204 Szczecin, Poland 4 Laboratory of Molecular Biology, Division of Perinatology and Women’s Diseases, Poznań University of Medical Sciences, 61-701 Poznan, Poland 9 Department of Medical Microbiology, Poznań University of Medical Sciences, 61-701 Poznan, Poland 7 Department of Pharmacology, Poznań University of Medical Sciences, 61-701 Poznan, Poland 5 Department of Stem Cells and Regenerative Medicine, Institute of Natural Fibres and Medicinal Plants, 60-630 Poznan, Poland 6 Department of Infertility and Reproductive Endocrinology, Poznań University of Medical Sciences, 61-701 Poznan, Poland 1 Division of Perinatology and Women’s Disease, Poznań University of Medical Sciences, 61-701 Poznan, Poland |
| AuthorAffiliation_xml | – name: 3 Department of Biotechnology, Institute of Natural Fibres and Medicinal Plants, 60-630 Poznan, Poland – name: 5 Department of Stem Cells and Regenerative Medicine, Institute of Natural Fibres and Medicinal Plants, 60-630 Poznan, Poland – name: 9 Department of Medical Microbiology, Poznań University of Medical Sciences, 61-701 Poznan, Poland – name: 7 Department of Pharmacology, Poznań University of Medical Sciences, 61-701 Poznan, Poland – name: 8 Department of General Pharmacology and Pharmacoeconomics, Pomeranian Medical University, 70-204 Szczecin, Poland – name: 2 Division of Obstetrics and Gynecology, Poviat Hospital, 34-500 Zakopane, Poland – name: 6 Department of Infertility and Reproductive Endocrinology, Poznań University of Medical Sciences, 61-701 Poznan, Poland – name: 1 Division of Perinatology and Women’s Disease, Poznań University of Medical Sciences, 61-701 Poznan, Poland – name: 4 Laboratory of Molecular Biology, Division of Perinatology and Women’s Diseases, Poznań University of Medical Sciences, 61-701 Poznan, Poland |
| Author_xml | – sequence: 1 givenname: Hubert surname: Wolski fullname: Wolski, Hubert – sequence: 2 givenname: Marcin orcidid: 0000-0003-2305-3116 surname: Ożarowski fullname: Ożarowski, Marcin – sequence: 3 givenname: Grażyna surname: Kurzawińska fullname: Kurzawińska, Grażyna – sequence: 4 givenname: Anna orcidid: 0000-0001-5455-8315 surname: Bogacz fullname: Bogacz, Anna – sequence: 5 givenname: Marlena surname: Wolek fullname: Wolek, Marlena – sequence: 6 givenname: Małgorzata surname: Łuszczyńska fullname: Łuszczyńska, Małgorzata – sequence: 7 givenname: Krzysztof surname: Drews fullname: Drews, Krzysztof – sequence: 8 givenname: Aleksandra E. surname: Mrozikiewicz fullname: Mrozikiewicz, Aleksandra E. – sequence: 9 givenname: Przemysław Ł. orcidid: 0000-0002-1252-6523 surname: Mikołajczak fullname: Mikołajczak, Przemysław Ł. – sequence: 10 givenname: Radosław orcidid: 0000-0002-2389-0689 surname: Kujawski fullname: Kujawski, Radosław – sequence: 11 givenname: Bogusław surname: Czerny fullname: Czerny, Bogusław – sequence: 12 givenname: Tomasz M. orcidid: 0000-0001-6599-9204 surname: Karpiński fullname: Karpiński, Tomasz M. – sequence: 13 givenname: Agnieszka surname: Seremak-Mrozikiewicz fullname: Seremak-Mrozikiewicz, Agnieszka |
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| Snippet | Background: Appropriate levels of cholesterol are necessary for the mother and developing fetus, but theirexcess may cause preeclampsia. The ABCA1 transporter... BACKGROUNDAppropriate levels of cholesterol are necessary for the mother and developing fetus, but theirexcess may cause preeclampsia. The ABCA1 transporter... |
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| SubjectTerms | Blood pressure Cholesterol Clinical medicine Diabetes Fetuses High density lipoprotein Hypertension Lipids Metabolism Placenta Preeclampsia Pregnancy Proteins Vascular endothelial growth factor Womens health |
| Title | Expression of ABCA1 Transporter and LXRA/LXRB Receptors in Placenta of Women with Late Onset Preeclampsia |
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