The Ex Vivo Production of IL-6 and IL-21 by CD4+ T Cells is Directly Associated with Neurological Disability in Neuromyelitis Optica Patients

Neuromyelitis optica (NMO), also known as Devic’s disease, is an autoimmune, inflammatory disorder of the central nervous system (CNS) in which the immune system attacks myelin of the neurons located at the optic nerves and spinal cord, thus producing a simultaneous or sequential optic neuritis and...

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Bibliographic Details
Published in:	Journal of clinical immunology Vol. 33; no. 1; pp. 179 - 189
Main Authors:	Linhares, Ulisses C., Schiavoni, Patrícia B., Barros, Priscila O., Kasahara, Taissa M., Teixeira, Bruna, Ferreira, Thais B., Alvarenga, Regina, Hygino, Joana, Vieira, Morgana M. M., Bittencourt, Vera Carolina B., Andrade, Regis M., Andrade, Arnaldo F., Bento, Cleonice A. M.
Format:	Journal Article
Language:	English
Published:	Boston Springer US 2013
Subjects:	Adult Biomedical and Life Sciences Biomedicine CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD4-Positive T-Lymphocytes - secretion Cells, Cultured Female Humans Immunology Infectious Diseases Interleukin-6 - biosynthesis Interleukin-6 - secretion Interleukins - biosynthesis Interleukins - secretion Internal Medicine Lymphocyte Activation - immunology Male Medical Microbiology Middle Aged Neuromyelitis Optica - immunology Neuromyelitis Optica - metabolism Neuromyelitis Optica - physiopathology Original Research glucocorticoid Neuromyelitis optica cytokines Th17 IL-21
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