Identification and preliminary structure–activity relationship of brain‐penetrant quinoxaline‐based compounds with in vitro anti‐glioblastoma activity

A central nervous system (CNS)‐oriented compound collection was screened to find hit compounds for human glioblastoma T98G cell growth inhibition. A series of quinoxaline‐based derivatives were identified as hit compounds having one‐ to two‐digit micromolar GI50 values. Anti‐glioblastoma activity wa...

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Bibliographic Details

Published in:	Bulletin of the Korean Chemical Society Vol. 44; no. 11; pp. 932 - 938
Main Authors:	Ahn, Seohyeon, Kim, Eun Hye, Lee, Chaemi, Nam, Yoon Chae, Lee, Joo‐Youn, Song, Jin Sook, Kim, Seong Hwan, Jeon, Moon‐Kook
Format:	Journal Article
Language:	English
Published:	Weinheim Wiley‐VCH Verlag GmbH & Co. KGaA 01-11-2023 대한화학회
Subjects:	brain penetration central nervous system glioblastoma growth inhibition quinoxaline 화학
Online Access:	Get full text
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