A randomized clinical comparison of OPTI-FREE EXPRESS and ReNu MultiPLUS multipurpose lens care solutions

• Published in: Advances in therapy Vol. 26; no. 4; pp. 435 - 446
• Main Author: Lipener, César
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer Healthcare Communications 01-04-2009
• Subjects: Adolescent; Adult; Aged; Biguanides - therapeutic use; Brazil; Cardiology; Conjunctivitis - chemically induced; Contact Lens Solutions - adverse effects; Contact Lens Solutions - chemistry; Contact Lens Solutions - therapeutic use; Cornea - drug effects; Cross-Over Studies; Double-Blind Method; Endocrinology; Female; Health technology assessment; Humans; Hyperemia - chemically induced; Internal Medicine; Male; Medicine; Medicine & Public Health; Middle Aged; Oncology; Original Research; Patient Satisfaction; Pharmacology/Toxicology; Polymers - therapeutic use; Propylamines - therapeutic use; Rheumatology; Statistics, Nonparametric; Surveys and Questionnaires; Xerophthalmia - chemically induced; multipurpose solution; conjunctival staining; OPTI-FREE; corneal staining; lens care products; ReNu; comfort
• ISSN: 0741-238X; 1865-8652
• DOI: 10.1007/s12325-009-0023-8

Objective
To evaluate subjective symptoms and clinical signs of tolerability and comfort in silicone and non-silicone hydrogel contact lens (CL) wearers using two different multipurpose solution (MPS) CL care regimens.
Methods
This was a randomized, double-masked, contralateral, crossover, multicenter (
n
=9) study. One hundred and eleven subjects were enrolled in the study, and were randomly assigned either silicone hydrogel CLs or non-silicone hydrogel CLs. Before wear, the CLs were randomly conditioned for at least 10 hours in a multipurpose disinfection solution (MPDS) preserved with either: Regimen 1-polyquaternium-1 0.001% and myristamidopropyl dimethylamine 0.0005% (POLYQUAD® and ALDOX®, respectively; OPTIFREE EXPRESS® MPDS, Alcon Laboratories, Inc., Fort Worth, TX, USA); or Regimen 2-multipurpose solution preserved with polyhexamethylene biguanide 0.0001% (PHMB, ReNu MultiPLUS® MPS, Bausch & Lomb, Rochester, NY, USA). The study had two in-office visits, 1 week apart. Subjects wore assigned CLs for approximately 4 hours at each visit. At each visit, subjects’ eyes were examined before CL insertion and at 2 hours and 4 hours after insertion. Corneal staining type and area, conjunctival staining, conjunctival injection, subjective symptoms (tolerability), and comfort were evaluated.
Results
One hundred and five subjects (210 eyes) completed the study. The total corneal staining score of area and type were statistically significantly less in Regimen 1 than in Regimen 2 (
P
<0.000001). The area of conjunctival staining was statistically significantly less in Regimen 1 than in Regimen 2 (
P
=0.03). No clinically significant hyperemia was observed for either regimen. Both tolerability (
P
=0.02) and patient preference (
P
=0.05) were in favor of Regimen 1.
Conclusions
Statistically significant clinical differences were evident between the two CL care regimens when used with silicone and non-silicone hydrogel CLs. OPTI-FREE EXPRESS MPDS users showed less corneal and conjunctival staining and reported greater comfort and tolerability to the CL/solution combination than ReNu MultiPLUS MPS users.