Pubescenes, jatrophane diterpenes, from Euphorbia pubescens, with multidrug resistance reversing activity on mouse lymphoma cells

The macrocyclic jatrophane diterpene polyesters, pubescenes A - D ( 1 - 4) were isolated from the whole dried plant of Euphorbia pubescens, and evaluated for multidrug resistance (MDR) reversing activity on mouse lymphoma cells. All the compounds displayed very strong activity compared with the posi...

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Bibliographic Details
Published in:	Planta medica Vol. 70; no. 1; p. 81
Main Authors:	Valente, Cláudia, Ferreira, Maria José, Abreu, Pedro M, Gyémánt, Nora, Ugocsai, Katalin, Hohmann, Judit, Molnár, Joseph
Format:	Journal Article
Language:	English
Published:	Germany 01-01-2004
Subjects:	Animals Cell Line, Tumor - drug effects Diterpenes - administration & dosage Diterpenes - adverse effects Diterpenes - pharmacology Diterpenes - therapeutic use Drug Resistance, Multiple Drug Resistance, Neoplasm - drug effects Euphorbia Lymphoma Magnetic Resonance Spectroscopy Mice Phytotherapy Plant Components, Aerial Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use
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Summary:	The macrocyclic jatrophane diterpene polyesters, pubescenes A - D ( 1 - 4) were isolated from the whole dried plant of Euphorbia pubescens, and evaluated for multidrug resistance (MDR) reversing activity on mouse lymphoma cells. All the compounds displayed very strong activity compared with the positive control verapamil. Pubescene D ( 4) is a new compound, whose structure was established as 3beta,9alpha,-diacetoxy-7beta-benzoyloxy-15beta-hydroxy-14-oxo-2beta H-jatropha-5 E,12 E-diene by spectroscopic methods, including (1)H- (1)H COSY, HMQC, HMBC and NOESY.
ISSN:	0032-0943
DOI:	10.1055/s-2004-815464