Discovery of reversible selective monoamine oxidase B inhibitors with anti-acetylcholinesterase activity derived from 4-oxo-N-4-diphenyl butanamides

Multitargeted drugs are essential for the treatment of various neurodegenerative disorders, because of their complex nature. This study aimed to develop novel small molecules as selective monoamine oxidase B (MAO-B) inhibitors with cholinesterase inhibition. With the help of fragment-based drug desi...

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Bibliographic Details

Published in:	Future medicinal chemistry Vol. 15; no. 2; pp. 189 - 210
Main Authors:	Jana, Srabanti, Nasreen, Tania, Singh, Sushil K
Format:	Journal Article
Language:	English
Published:	England Newlands Press Ltd 01-01-2023
Subjects:	Alzheimer’s disease cholinesterase fragment-based drug design Monoamine Oxidase - metabolism monoamine oxidase B Monoamine Oxidase Inhibitors - pharmacology Structure-Activity Relationship fragment-based drug design Alzheimer’s disease cholinesterase monoamine oxidase B
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