Cell calcium oscillations: the origin of their variability

Oscillation in calcium levels in the cytoplasm of individual cells has been observed experimentally to consist of a series of spikes and plateaux of differing amplitudes and inter-peak intervals. On the other hand, mathematical models based on known biochemical reaction kinetic behaviours predict, i...

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Bibliographic Details
Published in:	Medical & biological engineering & computing Vol. 43; no. 2; pp. 200 - 205
Main Authors:	Wood, A W, Cadusch, P J
Format:	Journal Article
Language:	English
Published:	United States Springer Nature B.V 01-03-2005
Subjects:	Behavior Calcium - metabolism Calcium Signaling - physiology Cytoplasm - metabolism Humans Mathematical models Models, Biological
Online Access:	Get full text
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Summary:	Oscillation in calcium levels in the cytoplasm of individual cells has been observed experimentally to consist of a series of spikes and plateaux of differing amplitudes and inter-peak intervals. On the other hand, mathematical models based on known biochemical reaction kinetic behaviours predict, in the main, limit cycle behaviour. Chaotic solutions do not mimic the observed variability, and so another solution was sought by the introduction of filtered noise into some of the kinetic coefficients. Some of the variability can be predicted from this mechanism, but it is likely that other sources contribute to this as well.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0140-0118 1741-0444
DOI:	10.1007/BF02345955