Modification of valsartan drug release by incorporation into sericin/alginate blend using experimental design methodology

• Published in: European polymer journal Vol. 153; p. 110506
• Main Authors: Santinon, Caroline, Dantas de Freitas, Emanuelle, Gurgel Carlos da Silva, Meuris, Gurgel Adeodato Vieira, Melissa
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 15-06-2021; Elsevier BV
• Subjects: Alginates; Design modifications; Design of experiments; Experimental design; Factorial design; Formulations; Mathematical analysis; Modified drug release; Pharmaceutical industry; Pharmaceuticals; Pharmacology; Polymers; Sericin and alginate blend; Side effects; Thermal stability; Valsartan; Modified drug release; Sericin and alginate blend; Valsartan; Experimental design
• ISSN: 0014-3057; 1873-1945
• DOI: 10.1016/j.eurpolymj.2021.110506

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•Sericin/alginate particles were produced for valsartan incorporation.•Evaluation of incorporation efficiency and drug loading with experimental design.•All formulations prolonged the valsartan release compared to the conventional form.•The sericin/alginate blend demonstrated compatibility with the drug.•Valsartan remained stable in the new pharmaceutical form.
Modifying pharmaceutical forms already available on the market is a strategy used by the pharmaceutical industries for optimizing the performance of different drugs. In the present study, a blend of sericin and alginate was proposed as a polymeric matrix for the incorporation of valsartan drug in order to prolong the release and maintain a more uniform concentration at patient’s organism, reducing the chance of side effects. A 2 full-factorial design was carried out aiming the evaluation of the variables involved and optimizing the process. The formulations that contained lower content of incorporated drug obtained less satisfactory results of incorporation efficiency, although these formulations had shown longer in vitro release profiles. Analytical characterization techniques confirmed the incorporation of the drug into the matrix and showed an increase in the thermal stability of the drug after its incorporation into the polymeric matrix. Accelerated stability study proved the stability of the pharmaceutical form after 6 months period.