Microemulsions incorporating Brosimum gaudichaudii extracts as a topical treatment for vitiligo: In vitro stimulation of melanocyte migration and pigmentation
The purpose of the study reported here was to develop and characterize microemulsions incorporating two ethanolic extracts of Brosimum gaudichaudii with different origins for topical application to treat the pigmentation disorder vitiligo. After plant extracts were obtained and submitted to in vitro...
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| Published in: | Journal of molecular liquids Vol. 294; p. 111685 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
15-11-2019
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| Abstract | The purpose of the study reported here was to develop and characterize microemulsions incorporating two ethanolic extracts of Brosimum gaudichaudii with different origins for topical application to treat the pigmentation disorder vitiligo. After plant extracts were obtained and submitted to in vitro biological assays against melanocytes, oil-in-water microemulsions incorporating the extracts were developed, characterized, and submitted to experiments to determine their stability, in vitro skin permeation, and irritant potential. The microemulsions were physically stable for at least 90 days and could incorporate the different concentrations of the furanocoumarins bergapten and psoralen from the Brosimum gaudichaudii extracts. Moreover, the microemulsions controlled the permeation of the furanocoumarins through the skin and were classified as weak irritants in a HET-CAM assay, which indicates their suitability for topical application. Although the extracts, by containing the furanocoumarins, stimulated melanocyte migration and pigmentation, their toxicity warrants caution. Nevertheless, because the findings suggest mechanisms by which the furanocoumarins can benefit the clinical treatment of vitiligo, microemulsions of them represent promising alternatives for topical application to treat the disorder.
•Brosimum gaudichaudii extracts stimulated in vitro melanocyte migration and pigmentation.•Microemulsions were stable and capable of incorporating B. gaudichaudii coumarins.•The formulations regulated coumarins permeation through the skin in vitro.•Microemulsions were classified as weak irritants and suitable for topical use.•The systems could be a promising alternative for topical vitiligo treatment. |
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| AbstractList | The purpose of the study reported here was to develop and characterize microemulsions incorporating two ethanolic extracts of Brosimum gaudichaudii with different origins for topical application to treat the pigmentation disorder vitiligo. After plant extracts were obtained and submitted to in vitro biological assays against melanocytes, oil-in-water microemulsions incorporating the extracts were developed, characterized, and submitted to experiments to determine their stability, in vitro skin permeation, and irritant potential. The microemulsions were physically stable for at least 90 days and could incorporate the different concentrations of the furanocoumarins bergapten and psoralen from the Brosimum gaudichaudii extracts. Moreover, the microemulsions controlled the permeation of the furanocoumarins through the skin and were classified as weak irritants in a HET-CAM assay, which indicates their suitability for topical application. Although the extracts, by containing the furanocoumarins, stimulated melanocyte migration and pigmentation, their toxicity warrants caution. Nevertheless, because the findings suggest mechanisms by which the furanocoumarins can benefit the clinical treatment of vitiligo, microemulsions of them represent promising alternatives for topical application to treat the disorder.
•Brosimum gaudichaudii extracts stimulated in vitro melanocyte migration and pigmentation.•Microemulsions were stable and capable of incorporating B. gaudichaudii coumarins.•The formulations regulated coumarins permeation through the skin in vitro.•Microemulsions were classified as weak irritants and suitable for topical use.•The systems could be a promising alternative for topical vitiligo treatment. |
| ArticleNumber | 111685 |
| Author | de Carvalho, Juliana Lott Gratieri, Tais Quintão, Wanessa de Souza Cardoso Gelfuso, Guilherme Martins Albernaz, Lorena C. Cunha-Filho, Marcilio Sá-Barreto, Livia C.L. Alencar-Silva, Thuany Borin, Maria de Fátima Rezende, Kennia Rocha |
| Author_xml | – sequence: 1 givenname: Wanessa de Souza Cardoso surname: Quintão fullname: Quintão, Wanessa de Souza Cardoso organization: Laboratory of Food, Drug and Cosmetics, School of Health Sciences, University of Brasilia, Brasília, DF 70910-900, Brazil – sequence: 2 givenname: Thuany surname: Alencar-Silva fullname: Alencar-Silva, Thuany organization: Laboratory of Biotechnology, Catholic University of Brasilia, Brasília, DF 70790-160, Brazil – sequence: 3 givenname: Maria de Fátima surname: Borin fullname: Borin, Maria de Fátima organization: Laboratory of Molecular Pharmacology, School of Health Sciences, University of Brasilia, Brasília, DF 70910-900, Brazil – sequence: 4 givenname: Kennia Rocha surname: Rezende fullname: Rezende, Kennia Rocha organization: BioPK Laboratory, Faculty of Pharmacy, Federal University of Goias, Goiânia, GO 74605-170, Brazil – sequence: 5 givenname: Lorena C. surname: Albernaz fullname: Albernaz, Lorena C. organization: Laboratory of Pharmacognosy, School of Health Sciences, University of Brasilia, Brasília, DF 70910-900, Brazil – sequence: 6 givenname: Marcilio surname: Cunha-Filho fullname: Cunha-Filho, Marcilio organization: Laboratory of Food, Drug and Cosmetics, School of Health Sciences, University of Brasilia, Brasília, DF 70910-900, Brazil – sequence: 7 givenname: Tais surname: Gratieri fullname: Gratieri, Tais organization: Laboratory of Food, Drug and Cosmetics, School of Health Sciences, University of Brasilia, Brasília, DF 70910-900, Brazil – sequence: 8 givenname: Juliana Lott surname: de Carvalho fullname: de Carvalho, Juliana Lott organization: Laboratory of Biotechnology, Catholic University of Brasilia, Brasília, DF 70790-160, Brazil – sequence: 9 givenname: Livia C.L. surname: Sá-Barreto fullname: Sá-Barreto, Livia C.L. organization: Laboratory of Food, Drug and Cosmetics, School of Health Sciences, University of Brasilia, Brasília, DF 70910-900, Brazil – sequence: 10 givenname: Guilherme Martins surname: Gelfuso fullname: Gelfuso, Guilherme Martins email: gmgelfuso@unb.br organization: Laboratory of Food, Drug and Cosmetics, School of Health Sciences, University of Brasilia, Brasília, DF 70910-900, Brazil |
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| Keywords | Vitiligo Topical Brosimum gaudichaudii Microemulsion Nanotechnology Skin permeation |
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| Title | Microemulsions incorporating Brosimum gaudichaudii extracts as a topical treatment for vitiligo: In vitro stimulation of melanocyte migration and pigmentation |
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