Highly efficient nonenzymatic glucose sensors based on CuO nanoparticles

• Published in: Applied surface science Vol. 481; pp. 712 - 722
• Main Authors: Ashok, Anchu, Kumar, Anand, Tarlochan, Faris
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-07-2019
• Subjects: Colloidal synthesis; CuO; Glucose sensor materials; Non-enzymatic sensors; Solution combustion synthesis; Solution combustion synthesis; Non-enzymatic sensors; CuO; Colloidal synthesis; Glucose sensor materials
• ISSN: 0169-4332; 1873-5584
• DOI: 10.1016/j.apsusc.2019.03.157

In this work, copper nanoparticles using three different modes are synthesized and evaluated for electrochemical properties towards non-enzymatic glucose biosensors. Copper oxide nanoparticles thus obtained are characterized using X-ray diffractometer (XRD), Scanning Electron Microscope (SEM), transmission electron microscopy (TEM) and UV–Vis for their crystallinity, morphology and optical properties. The nanoparticles obtained using colloidal method (Cu-Colloid) give uniform phase of CuO and flower shaped morphology. The nanoparticles synthesized using solution combustion method with glycine (Cu-Gly) and hydrazine (Cu-Hyd) as fuel provide particles of irregular round shape and small flake-like structures respectively. The glucose electro oxidative current is highest for Cu-Colloid catalysts and could be due to the higher area of contact of the catalyst surface with the glucose. Cu-colloid particles with flower shaped morphology give wide linear response in the range of 1 μM to 850 μM along with the lowest limit of detection of 0.25 μM and highest sensitivity of 2062 μA mM−1 cm−2. Cu-Colloid catalyst show poor response on the presence of co-existing species on the blood sample when compared to its sensitivity towards glucose. The time response of Cu-Colloid particles for glucose detection is the least when compared to other two nanoparticles. Also, the Cu-Colloid particles show excellent reproducibility and stability that makes it a promising electrode for the non-enzymatic glucose bio-sensors.
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•CuO nanostructures were synthesized using colloidal and combustion based techniques.•CuO nanoflower synthesized using colloidal method showed high activity and stability for glucose sensing application.•Synthesis methods affect the CuO nanostructure formation and electrocatalytic properties.