Distinct ongoing Ig heavy chain rearrangement processes in childhood B- precursor acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is thought to arise from the clonal expansion of a single transformed precursor cell. However, an oligoclonal Ig heavy chain (IgH) rearrangement pattern has been observed in 30% of ALL patients and was shown to be the result of ongoing rearrangement events. The ext...

Full description

Saved in:

Bibliographic Details
Published in:	Blood Vol. 82; no. 2; pp. 581 - 589
Main Authors:	Steenbergen, Eric J., Verhagen, Onno J.H.M., van Leeuwen, Eleonore F., von dem Borne, Albert E.G. Kr, van der Schoot, C. Ellen
Format:	Journal Article
Language:	English
Published:	Washington, DC Elsevier Inc 15-07-1993 The Americain Society of Hematology
Subjects:	Adolescent Base Sequence Biological and medical sciences Blast Crisis Blotting, Southern Child Child, Preschool Gene Rearrangement Hematologic and hematopoietic diseases Humans Immunoglobulin Heavy Chains - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Molecular Sequence Data Polymerase Chain Reaction Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - immunology Human Immunoglobulins heavy-Peptide chain Gene rearrangement Malignant hemopathy Acute lymphocytic leukemia Molecular biology Child
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!