Suppression of growth and metastasizing of T-cell lymphoma in mice infected with american trypanosomiasis at different stages of experimental infection

Antitumor activity of Trypanosoma cruzi CH4 strain isolated in Mexico was studied. This parasite is not tumoritropic, but inhibits the growth and metastasizing of solid L5178Y-R lymphoma transplanted to Balb/C mice. Conditioned medium from cell cultures infected with this strain produced a cytostati...

Full description

Saved in:

Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 137; no. 5; pp. 475 - 478
Main Authors:	Mel'nikov, V G, Fierro Velasko, F H, Dobrovinskaya, O R
Format:	Journal Article
Language:	English
Published:	United States Springer Nature B.V 01-05-2004
Subjects:	Animals Cell Proliferation - drug effects Chagas Disease - complications Chagas Disease - parasitology Culture Media, Conditioned - pharmacology Lymphoma, T-Cell - complications Lymphoma, T-Cell - parasitology Lymphoma, T-Cell - pathology Male Mice Mice, Inbred BALB C Muscles - parasitology Neoplasm Metastasis Trypanosoma cruzi Tumor Burden
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Antitumor activity of Trypanosoma cruzi CH4 strain isolated in Mexico was studied. This parasite is not tumoritropic, but inhibits the growth and metastasizing of solid L5178Y-R lymphoma transplanted to Balb/C mice. Conditioned medium from cell cultures infected with this strain produced a cytostatic effect. Possible mechanisms of this phenomenon are discussed.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-4888 1573-8221
DOI:	10.1023/B:BEBM.0000038157.69208.27