Risk Factors and Outcomes After a Brief Resolved Unexplained Event: A Multicenter Study

• Published in: Pediatrics (Evanston) Vol. 148; no. 1
• Main Authors: Tieder, Joel S., Sullivan, Erin, Stephans, Allayne, Hall, Matt, DeLaroche, Amy M., Wilkins, Victoria, Neuman, Mark I., Mittal, Manoj K., Kane, Emily, Jain, Shobhit, Shastri, Nirav, Katsogridakis, Yiannis, Vachani, Joyee G., Hochreiter, Daniela, Kim, Edward, Nicholson, Jessica, Bochner, Risa, Murphy, Kathleen
• Format: Journal Article
• Language: English
• Published: Evanston American Academy of Pediatrics 01-07-2021
• Subjects: Clinical outcomes; Diagnosis; Diseases; Emergency medical care; Infants (Newborn); Neonatal diseases; Patients; Pediatrics; Risk factors; Seizures; Uncertainty in illness; United States
• ISSN: 0031-4005; 1098-4275
• DOI: 10.1542/peds.2020-036095

BACKGROUND The accuracy of the risk criteria for brief resolved unexplained events (BRUEs) from the American Academy of Pediatrics (AAP) is unknown. We sought to evaluate if AAP risk criteria and event characteristics predict BRUE outcomes. METHODS This retrospective cohort included infants <1 year of age evaluated in the emergency departments (EDs) of 15 pediatric and community hospitals for a BRUE between October 1, 2015, and September 30, 2018. A multivariable regression model was used to evaluate the association of AAP risk factors and event characteristics with risk for event recurrence, revisits, and serious diagnoses explaining the BRUE. RESULTS Of 2036 patients presenting with a BRUE, 87% had at least 1 AAP higher-risk factor. Revisits occurred in 6.9% of ED and 10.7% of hospital discharges. A serious diagnosis was made in 4.0% (82) of cases; 45% (37) of these diagnoses were identified after the index visit. The most common serious diagnoses included seizures (1.1% [23]) and airway abnormalities (0.64% [13]). Risk is increased for a serious underlying diagnosis for patients discharged from the ED with a history of a similar event, an event duration >1 minute, an abnormal medical history, and an altered responsiveness (P < .05). AAP risk criteria for all outcomes had a negative predictive value of 90% and a positive predictive value of 23%. CONCLUSIONS AAP BRUE risk criteria are used to accurately identify patients at low risk for event recurrence, readmission, and a serious underlying diagnosis; however, their use results in the inaccurate identification of many patients as higher risk. This is likely because many AAP risk factors, such as age, are not associated with these outcomes.