Aspects of cognitive assessments and spectroscopic magnetic resonance imaging in people with chronic hepatitis C: a systematic review

Extrahepatic manifestations are common in people with hepatitis C virus (HCV). Cognitive changes are pointed out, but the mechanisms are still uncertain. The aim of this systematic review was to analyze studies involving spectroscopic magnetic resonance in people infected with HCV, which also includ...

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Published in:	Psychology, health & medicine Vol. 28; no. 4; pp. 1013 - 1029
Main Authors:	Carvalho, Tatiana Lins, Mertens Brainer de Queiroz Lima, Alessandra Cintia, de Araújo, Noemi Salazar, de Sousa Fernandes, Matheus Santos, Lira, Gabriela Barza, de Melo, Marcela Maria Medeiros, Vasconcelos, Luydson Richardson Silva, de Moura, Patrícia Muniz Mendes Freire, da Cunha Correia, Carolina
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 21-04-2023 Taylor & Francis Ltd
Subjects:	Brain - pathology Cognition Cognition Disorders Cognitive change cognitive dysfunction Confounding factors Fluency Hepatitis C hepatitis c chronic Hepatitis C, Chronic - pathology Humans Information processing Magnetic Resonance Imaging magnetic resonance spectroscopy Systematic review Verbal memory magnetic resonance spectroscopy Cognition hepatitis c chronic cognitive dysfunction hepatitis c
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Abstract	Extrahepatic manifestations are common in people with hepatitis C virus (HCV). Cognitive changes are pointed out, but the mechanisms are still uncertain. The aim of this systematic review was to analyze studies involving spectroscopic magnetic resonance in people infected with HCV, which also included cognitive tests. The research occurred in six databases (Directory of Open Access Journals, Lilacs, Medcaribe, Medline, Scielo and ScienceDirect) and the selection of studies was carried out in two stages: search for titles and abstracts, then reading of the full articles, excluding those that did not meet the eligibility criteria. 12,888 titles and abstracts were selected, but only 6 articles were included in the review. Impairments in attention, concentration, speed of information processing, memory, verbal fluency and executive functions were identified as well as an increase in the Cho/Cr and mI/Cr ratios and a reduction in the NAA/Cr ratio in some included studies. Longitudinal studies, with more homogeneous samples and methods, as well as with better controlled confounding factors, are necessary to adequately identify the effect of HCV on the brain.
AbstractList	Extrahepatic manifestations are common in people with hepatitis C virus (HCV). Cognitive changes are pointed out, but the mechanisms are still uncertain. The aim of this systematic review was to analyze studies involving spectroscopic magnetic resonance in people infected with HCV, which also included cognitive tests. The research occurred in six databases (Directory of Open Access Journals, Lilacs, Medcaribe, Medline, Scielo and ScienceDirect) and the selection of studies was carried out in two stages: search for titles and abstracts, then reading of the full articles, excluding those that did not meet the eligibility criteria. 12,888 titles and abstracts were selected, but only 6 articles were included in the review. Impairments in attention, concentration, speed of information processing, memory, verbal fluency and executive functions were identified as well as an increase in the Cho/Cr and mI/Cr ratios and a reduction in the NAA/Cr ratio in some included studies. Longitudinal studies, with more homogeneous samples and methods, as well as with better controlled confounding factors, are necessary to adequately identify the effect of HCV on the brain.
Author	Lira, Gabriela Barza Carvalho, Tatiana Lins de Sousa Fernandes, Matheus Santos da Cunha Correia, Carolina Vasconcelos, Luydson Richardson Silva Mertens Brainer de Queiroz Lima, Alessandra Cintia de Moura, Patrícia Muniz Mendes Freire de Araújo, Noemi Salazar de Melo, Marcela Maria Medeiros
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SubjectTerms	Brain - pathology Cognition Cognition Disorders Cognitive change cognitive dysfunction Confounding factors Fluency Hepatitis C hepatitis c chronic Hepatitis C, Chronic - pathology Humans Information processing Magnetic Resonance Imaging magnetic resonance spectroscopy Systematic review Verbal memory
Title	Aspects of cognitive assessments and spectroscopic magnetic resonance imaging in people with chronic hepatitis C: a systematic review
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