Efficient synthesis of 4-phosphinoyl-4,5,6,7-tetrahydro-2H-indazol-3-ylamines

We described in this paper an efficient synthesis of variously substituted 4-phosphinoyl-4,5,6,7-tetrahydro-2H-indazol-3-ylamines involving nucleophilic addition of hydrazine on beta -ketothioamides as key-step.

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Bibliographic Details
Published in:	Tetrahedron Vol. 67; no. 48; pp. 9440 - 9445
Main Authors:	JELAIEL, Nourchaine, COMOY, Corinne, FERNETTE, Brigitte, LOFTI EFRIT, Mohamed, FORT, Yves
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier 02-12-2011
Subjects:	Alicyclic compounds Alicyclic compounds, terpenoids, prostaglandins, steroids Chemical Sciences Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Hydrazines Organic chemistry Preparations and properties Synthesis (chemistry) Tetrahedrons indazol-3-ylamines Nitrogen heterocycle 4-Phosphinoyl-4,5,6,7-tetrahydro-2H debenzoylation Ketone Indazole derivatives Phosphorus Organic compounds Tertiary phosphine oxide Cyclohexanone derivative Thioamide 3-Phosphorylcyclohexanones Deacetylation Alternative deacetylation and β-Phosphorylthioamides Hydrazine Chemical synthesis Nucleophilic addition
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Summary:	We described in this paper an efficient synthesis of variously substituted 4-phosphinoyl-4,5,6,7-tetrahydro-2H-indazol-3-ylamines involving nucleophilic addition of hydrazine on beta -ketothioamides as key-step.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0040-4020 1464-5416
DOI:	10.1016/j.tet.2011.09.093