The fenestrae-associated protein Plvap regulates the rate of blood-borne protein passage into the hypophysis
To maintain body homeostasis, endocrine systems must detect and integrate blood-borne peripheral signals. This is mediated by fenestrae, specialized permeable pores in the endothelial membrane. Plasmalemma vesicle-associated protein (Plvap) is located in the fenestral diaphragm and is thought to pla...
Saved in:
| Published in: | Development (Cambridge) Vol. 146; no. 23 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
The Company of Biologists Ltd
02-12-2019
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | To maintain body homeostasis, endocrine systems must detect and integrate blood-borne peripheral signals. This is mediated by fenestrae, specialized permeable pores in the endothelial membrane. Plasmalemma vesicle-associated protein (Plvap) is located in the fenestral diaphragm and is thought to play a role in the passage of proteins through the fenestrae. However, this suggested function has yet to be demonstrated directly. We studied the development of fenestrated capillaries in the hypophysis, a major neuroendocrine interface between the blood and brain. Using a transgenic biosensor to visualize the vascular excretion of the genetically tagged plasma protein DBP-EGFP, we show that the developmental acquisition of vascular permeability coincides with differential expression of zebrafish
orthologs in the hypophysis versus brain. Ultrastructural analysis revealed that
mutants display deficiencies in fenestral diaphragms and increased density of hypophyseal fenestrae. Measurements of DBP-EGFP extravasation in
mutants provided direct proof that Plvap limits the rate of blood-borne protein passage through fenestrated endothelia. We present the regulatory role of Plvap in the development of blood-borne protein detection machinery at a neuroendocrine interface through which hormones are released to the general circulation. |
|---|---|
| AbstractList | To maintain body homeostasis, endocrine systems must detect and integrate blood-borne peripheral signals. This is mediated by fenestrae, specialized permeable pores in the endothelial membrane. Plasmalemma vesicle-associated protein (Plvap) is located in the fenestral diaphragm and is thought to play a role in the passage of proteins through the fenestrae. However, this suggested function has yet to be demonstrated directly. We studied the development of fenestrated capillaries in the hypophysis, a major neuroendocrine interface between the blood and brain. Using a transgenic biosensor to visualize the vascular excretion of the genetically tagged plasma protein DBP-EGFP, we show that the developmental acquisition of vascular permeability coincides with differential expression of zebrafish
orthologs in the hypophysis versus brain. Ultrastructural analysis revealed that
mutants display deficiencies in fenestral diaphragms and increased density of hypophyseal fenestrae. Measurements of DBP-EGFP extravasation in
mutants provided direct proof that Plvap limits the rate of blood-borne protein passage through fenestrated endothelia. We present the regulatory role of Plvap in the development of blood-borne protein detection machinery at a neuroendocrine interface through which hormones are released to the general circulation. To maintain body homeostasis, endocrine systems must detect and integrate blood-borne peripheral signals. This is mediated by fenestrae, specialized permeable pores in the endothelial membrane. Plasmalemma vesicle-associated protein (Plvap) is located in the fenestral diaphragm and is thought to play a role in the passage of proteins through the fenestrae. However, this suggested function has yet to be demonstrated directly. We studied the development of fenestrated capillaries in the hypophysis, a major neuroendocrine interface between the blood and brain. Using a transgenic biosensor to visualize the vascular excretion of the genetically tagged plasma protein DBP-EGFP, we show that the developmental acquisition of vascular permeability coincides with differential expression of zebrafish plvap orthologs in the hypophysis versus brain. Ultrastructural analysis revealed that plvapb mutants display deficiencies in fenestral diaphragms and increased density of hypophyseal fenestrae. Measurements of DBP-EGFP extravasation in plvapb mutants provided direct proof that Plvap limits the rate of blood-borne protein passage through fenestrated endothelia. We present the regulatory role of Plvap in the development of blood-borne protein detection machinery at a neuroendocrine interface through which hormones are released to the general circulation. To maintain body homeostasis, endocrine systems must detect and integrate blood-borne peripheral signals. This is mediated by fenestrae, specialized permeable pores in the endothelial membrane. Plasmalemma vesicle-associated protein (Plvap) is located in the fenestral diaphragm and is thought to play a role in the passage of proteins through the fenestrae. However, this suggested function has yet to be demonstrated directly. We studied the development of fenestrated capillaries in the hypophysis, a major neuroendocrine interface between the blood and brain. Using a transgenic biosensor to visualize the vascular excretion of the genetically tagged plasma protein DBP-EGFP, we show that the developmental acquisition of vascular permeability coincides with differential expression of zebrafish plvap orthologs in the hypophysis versus brain. Ultrastructural analysis revealed that plvapb mutants display deficiencies in fenestral diaphragms and increased density of hypophyseal fenestrae. Measurements of DBP-EGFP extravasation in plvapb mutants provided direct proof that Plvap limits the rate of blood-borne protein passage through fenestrated endothelia. We present the regulatory role of Plvap in the development of blood-borne protein detection machinery at a neuroendocrine interface through which hormones are released to the general circulation. Summary: Fenestrae play a principal role in regulation of homeostasis. The fenestral protein Plvap regulates the rate of plasma protein entry from the general circulation into the brain parenchyma. |
| Author | Gur, Dvir Shimoni, Eyal Anand-Apte, Bela Blechman, Janna Levkowitz, Gil Gordon, Ludmila |
| AuthorAffiliation | 2 Chemical Research Support , Weizmann Institute of Science , PO Box 26, Rehovot 7610001 , Israel 1 Department of Molecular Cell Biology , Weizmann Institute of Science , PO Box 26, Rehovot 7610001 , Israel 3 Department of Ophthalmic Research , Cole Eye Institute, Cleveland Clinic Foundation , Cleveland OH 444195 , USA |
| AuthorAffiliation_xml | – name: 1 Department of Molecular Cell Biology , Weizmann Institute of Science , PO Box 26, Rehovot 7610001 , Israel – name: 3 Department of Ophthalmic Research , Cole Eye Institute, Cleveland Clinic Foundation , Cleveland OH 444195 , USA – name: 2 Chemical Research Support , Weizmann Institute of Science , PO Box 26, Rehovot 7610001 , Israel |
| Author_xml | – sequence: 1 givenname: Ludmila orcidid: 0000-0003-4525-0786 surname: Gordon fullname: Gordon, Ludmila organization: Department of Molecular Cell Biology, Weizmann Institute of Science, PO Box 26, Rehovot 7610001, Israel – sequence: 2 givenname: Janna surname: Blechman fullname: Blechman, Janna organization: Department of Molecular Cell Biology, Weizmann Institute of Science, PO Box 26, Rehovot 7610001, Israel – sequence: 3 givenname: Eyal surname: Shimoni fullname: Shimoni, Eyal organization: Chemical Research Support, Weizmann Institute of Science, PO Box 26, Rehovot 7610001, Israel – sequence: 4 givenname: Dvir orcidid: 0000-0002-9140-1621 surname: Gur fullname: Gur, Dvir organization: Department of Molecular Cell Biology, Weizmann Institute of Science, PO Box 26, Rehovot 7610001, Israel – sequence: 5 givenname: Bela surname: Anand-Apte fullname: Anand-Apte, Bela organization: Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland OH 444195, USA – sequence: 6 givenname: Gil orcidid: 0000-0002-3896-1881 surname: Levkowitz fullname: Levkowitz, Gil email: gil.levkowitz@weizmann.ac.il organization: Department of Molecular Cell Biology, Weizmann Institute of Science, PO Box 26, Rehovot 7610001, Israel gil.levkowitz@weizmann.ac.il |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31740533$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVkVtLwzAUx4Mo7qIvfgDpowidubRN8yLI8AYDfZjPIUlPt0qX1KQb7NubuTn0KYec3_mfy3-ETq2zgNAVwRNCM3pXwWZCOOcCn6AhyThPBaHiFA2xyHFKhCADNArhE2PMCs7P0YARnuGcsSFq50tIarAQeq8gVSE406geqqTzrofGJu_tRnWJh8W6jf8h6WOBj1Hi6kS3zlWpdt7Cke-ihlpA0tje_cDLbee65TY04QKd1aoNcHl4x-jj6XE-fUlnb8-v04dZalhG-zQ3paqVAgpAOc41z7JMaMNYbbJScI1xTg0ti5yyQmhOdFmSmmpdFhVntDBsjO73ut1ar6AyYONyrex8s1J-K51q5P-MbZZy4TayEKTkJYsCNwcB777W8TZy1QQDbassuHWQlJFc8DjcDr3do8a7EDzUxzYEy509Mtoj9_ZE-PrvYEf01w_2Db_vj7c |
| CitedBy_id | crossref_primary_10_1007_s00441_020_03273_y crossref_primary_10_1038_s41598_020_79313_y crossref_primary_10_1159_000519233 crossref_primary_10_7554_eLife_86066 crossref_primary_10_1016_j_celrep_2024_114395 crossref_primary_10_1007_s00018_022_04403_1 crossref_primary_10_1002_glia_23849 crossref_primary_10_3389_frym_2021_534184 crossref_primary_10_1016_j_celrep_2024_114331 crossref_primary_10_1523_ENEURO_0345_19_2019 |
| Cites_doi | 10.1136/jmedgenet-2018-105262 10.1073/pnas.0603501103 10.1016/j.jmb.2004.03.016 10.1152/ajpheart.00133.2005 10.7554/eLife.22170 10.3389/fnins.2015.00390 10.1016/j.bbamcr.2005.08.008 10.1016/j.jsb.2005.07.007 10.1016/S0022-5320(65)80056-9 10.1016/j.jcmgh.2015.05.001 10.1006/jsbi.1996.0013 10.1073/pnas.96.23.13203 10.1111/j.1582-4934.2007.00075.x 10.1159/000358313 10.1038/nprot.2008.73 10.1186/1471-213X-10-76 10.1242/dev.080226 10.1016/S0022-5320(62)90052-7 10.1016/j.ydbio.2017.03.017 10.1096/fj.201801499RRR 10.1002/9781118760369.ch14 10.1177/000331976101200704 10.1002/advs.201800338 10.1083/jcb.37.3.633 10.1083/jcb.17.1.208 10.1159/000124678 10.1007/s00418-012-0987-3 10.1161/01.RES.0000255691.76142.4a 10.1210/en.2009-0584 10.1002/aja.1002020402 10.1091/mbc.e03-08-0593 10.1016/j.devcel.2018.10.017 10.1007/BF00212526 10.1038/s41586-019-1064-z 10.1523/JNEUROSCI.1798-11.2011 10.1084/jem.20072041 10.1093/nar/gky1100 10.3892/etm.2016.3557 10.1016/j.devcel.2012.11.003 10.1111/jcmm.13993 10.1016/j.devcel.2011.09.004 10.3389/fendo.2017.00275 10.1046/j.1440-1681.2000.03259.x 10.1002/jcb.26793 |
| ContentType | Journal Article |
| Copyright | 2019. Published by The Company of Biologists Ltd. 2019. Published by The Company of Biologists Ltd 2019 |
| Copyright_xml | – notice: 2019. Published by The Company of Biologists Ltd. – notice: 2019. Published by The Company of Biologists Ltd 2019 |
| DBID | NPM AAYXX CITATION 7X8 5PM |
| DOI | 10.1242/dev.177790 |
| DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | PubMed CrossRef |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Zoology Biology |
| EISSN | 1477-9129 |
| ExternalDocumentID | 10_1242_dev_177790 31740533 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: NEI NIH HHS grantid: R01 EY026181 – fundername: NEI NIH HHS grantid: P30 EY025585 – fundername: NEI NIH HHS grantid: R01 EY027083 – fundername: ; – fundername: ; grantid: EY026181; EY027083; P30EY025585 – fundername: ; grantid: 1511/16 |
| GroupedDBID | --- -DZ -ET -~X .55 0R~ 18M 2WC 34G 39C 4.4 53G 5GY 5RE 5VS 85S AAFWJ ABZEH ACGFS ACPRK ACREN ADBBV ADFRT AENEX AFFNX AGGIJ ALMA_UNASSIGNED_HOLDINGS AMTXH BAWUL BTFSW CS3 DIK DU5 E3Z EBS EJD F5P F9R GX1 H13 HZ~ INIJC KQ8 NPM O9- OK1 P2P R.V RCB RHF RHI SJN TR2 TWZ UPT W8F WH7 WOQ X7M XSW AAYXX CITATION 7X8 5PM |
| ID | FETCH-LOGICAL-c342t-5c8afaae2ee2705b74449bc33fc4897b0052c28652369b71b881f2bb86d7326c3 |
| ISSN | 0950-1991 |
| IngestDate | Tue Sep 17 21:23:00 EDT 2024 Fri Oct 25 08:30:37 EDT 2024 Thu Nov 21 23:46:05 EST 2024 Sat Sep 28 08:39:27 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 23 |
| Keywords | Fenestrae Blood-brain barrier Neuroendocrine Pituitary Circumventricular organs Homeostasis Zebrafish PV1 Hypothalamus Vascular permeability Neurohypophysis PV-1 |
| Language | English |
| License | 2019. Published by The Company of Biologists Ltd. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c342t-5c8afaae2ee2705b74449bc33fc4897b0052c28652369b71b881f2bb86d7326c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-3896-1881 0000-0002-9140-1621 0000-0003-4525-0786 |
| PMID | 31740533 |
| PQID | 2315972703 |
| PQPubID | 23479 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6918783 proquest_miscellaneous_2315972703 crossref_primary_10_1242_dev_177790 pubmed_primary_31740533 |
| PublicationCentury | 2000 |
| PublicationDate | 20191202 |
| PublicationDateYYYYMMDD | 2019-12-02 |
| PublicationDate_xml | – month: 12 year: 2019 text: 20191202 day: 2 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Development (Cambridge) |
| PublicationTitleAlternate | Development |
| PublicationYear | 2019 |
| Publisher | The Company of Biologists Ltd |
| Publisher_xml | – name: The Company of Biologists Ltd |
| References | van der Wijk (2024053017562487100_DEV177790C42) 2019; 33 Mastronarde (2024053017562487100_DEV177790C26) 2005; 152 Stan (2024053017562487100_DEV177790C39) 2004; 15 Hamilton (2024053017562487100_DEV177790C17) 2019; 23 Elkadri (2024053017562487100_DEV177790C8) 2015; 1 Schaeffer (2024053017562487100_DEV177790C34) 2014; 42 Aird (2024053017562487100_DEV177790C1) 2007; 100 Broekaert (2024053017562487100_DEV177790C4) 2018; 55 Holmes (2024053017562487100_DEV177790C19) 1974 Gross (2024053017562487100_DEV177790C12) 1986; 44 Anbalagan (2024053017562487100_DEV177790C2) 2018; 47 Ciofi (2024053017562487100_DEV177790C5) 2009; 150 Stan (2024053017562487100_DEV177790C40) 2012; 23 Reynolds (2024053017562487100_DEV177790C32) 1963; 17 Rhodin (2024053017562487100_DEV177790C33) 1962; 6 Filippini (2024053017562487100_DEV177790C10) 2018; 119 Herrnberger (2024053017562487100_DEV177790C18) 2012; 138 Xie (2024053017562487100_DEV177790C45) 2010; 10 Mitchell (2024053017562487100_DEV177790C28) 2018; 47 Umans (2024053017562487100_DEV177790C41) 2017; 425 Gur (2024053017562487100_DEV177790C14) 2018; 5 Ioannidou (2024053017562487100_DEV177790C20) 2006; 103 Stan (2024053017562487100_DEV177790C37) 2007; 11 Wircer (2024053017562487100_DEV177790C44) 2017; 6 Liu (2024053017562487100_DEV177790C24) 2013; 140 Wircer (2024053017562487100_DEV177790C43) 2016 Milici (2024053017562487100_DEV177790C27) 1986; 244 Käll (2024053017562487100_DEV177790C21) 2004; 338 Blechman (2024053017562487100_DEV177790C3) 2011; 31 Kremer (2024053017562487100_DEV177790C23) 1996; 116 Miyata (2024053017562487100_DEV177790C29) 2015; 9 Palade (2024053017562487100_DEV177790C31) 1968; 37 Gutnick (2024053017562487100_DEV177790C15) 2011; 21 Farquhar (2024053017562487100_DEV177790C9) 1961; 12 Maharaj (2024053017562487100_DEV177790C25) 2008; 205 Miyata (2024053017562487100_DEV177790C30) 2017; 8 Guo (2024053017562487100_DEV177790C13) 2016; 12 Ganong (2024053017562487100_DEV177790C11) 2000; 27 Schmittgen (2024053017562487100_DEV177790C35) 2008; 3 Stan (2024053017562487100_DEV177790C36) 2005; 1746 El-Brolosy (2024053017562487100_DEV177790C6) 2019; 568 Elfvin (2024053017562487100_DEV177790C7) 1965; 12 Kamba (2024053017562487100_DEV177790C22) 2006; 290 Stan (2024053017562487100_DEV177790C38) 1999; 96 Hallmann (2024053017562487100_DEV177790C16) 1995; 202 |
| References_xml | – volume: 55 start-page: 637 year: 2018 ident: 2024053017562487100_DEV177790C4 article-title: Mutations in plasmalemma vesicle-associated protein cause severe syndromic protein-losing enteropathy publication-title: J. Med. Genet. doi: 10.1136/jmedgenet-2018-105262 contributor: fullname: Broekaert – volume: 103 start-page: 16770 year: 2006 ident: 2024053017562487100_DEV177790C20 article-title: An in vitro assay reveals a role for the diaphragm protein PV-1 in endothelial fenestra morphogenesis publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0603501103 contributor: fullname: Ioannidou – volume: 338 start-page: 1027 year: 2004 ident: 2024053017562487100_DEV177790C21 article-title: A combined transmembrane topology and signal peptide prediction method publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2004.03.016 contributor: fullname: Käll – volume: 290 start-page: H560 year: 2006 ident: 2024053017562487100_DEV177790C22 article-title: VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature publication-title: Am. J. Physiol. Heart Circ. Physiol. doi: 10.1152/ajpheart.00133.2005 contributor: fullname: Kamba – volume: 6 start-page: e22170 year: 2017 ident: 2024053017562487100_DEV177790C44 article-title: Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior publication-title: Elife doi: 10.7554/eLife.22170 contributor: fullname: Wircer – volume: 9 start-page: 390 year: 2015 ident: 2024053017562487100_DEV177790C29 article-title: New aspects in fenestrated capillary and tissue dynamics in the sensory circumventricular organs of adult brains publication-title: Front. Neurosci. doi: 10.3389/fnins.2015.00390 contributor: fullname: Miyata – volume: 1746 start-page: 334 year: 2005 ident: 2024053017562487100_DEV177790C36 article-title: Structure of caveolae publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamcr.2005.08.008 contributor: fullname: Stan – volume: 152 start-page: 36 year: 2005 ident: 2024053017562487100_DEV177790C26 article-title: Automated electron microscope tomography using robust prediction of specimen movements publication-title: J. Struct. Biol. doi: 10.1016/j.jsb.2005.07.007 contributor: fullname: Mastronarde – volume: 12 start-page: 687 year: 1965 ident: 2024053017562487100_DEV177790C7 article-title: The ultrastructure of the capillary fenestrae in the adrenal medulla of the rat publication-title: J. Ultrastruct. Res. doi: 10.1016/S0022-5320(65)80056-9 contributor: fullname: Elfvin – volume: 1 start-page: 381 year: 2015 ident: 2024053017562487100_DEV177790C8 article-title: Mutations in Plasmalemma vesicle associated protein result in sieving protein-losing enteropathy characterized by hypoproteinemia, hypoalbuminemia, and hypertriglyceridemia publication-title: Cell Mol. Gastroenterol. Hepatol. doi: 10.1016/j.jcmgh.2015.05.001 contributor: fullname: Elkadri – volume: 116 start-page: 71 year: 1996 ident: 2024053017562487100_DEV177790C23 article-title: Computer visualization of three-dimensional image data using IMOD publication-title: J. Struct. Biol. doi: 10.1006/jsbi.1996.0013 contributor: fullname: Kremer – volume: 96 start-page: 13203 year: 1999 ident: 2024053017562487100_DEV177790C38 article-title: PV-1 is a component of the fenestral and stomatal diaphragms in fenestrated endothelia publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.96.23.13203 contributor: fullname: Stan – volume: 11 start-page: 621 year: 2007 ident: 2024053017562487100_DEV177790C37 article-title: Endothelial stomatal and fenestral diaphragms in normal vessels and angiogenesis publication-title: J. Cell. Mol. Med. doi: 10.1111/j.1582-4934.2007.00075.x contributor: fullname: Stan – volume: 42 start-page: 29 year: 2014 ident: 2024053017562487100_DEV177790C34 article-title: The blood-brain barrier as a regulator of the gut-brain axis publication-title: Front. Horm. Res. doi: 10.1159/000358313 contributor: fullname: Schaeffer – volume: 3 start-page: 1101 year: 2008 ident: 2024053017562487100_DEV177790C35 article-title: Analyzing real-time PCR data by the comparative CT method publication-title: Nat. Protoc. doi: 10.1038/nprot.2008.73 contributor: fullname: Schmittgen – volume: 10 year: 2010 ident: 2024053017562487100_DEV177790C45 article-title: A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development publication-title: BMC Dev. Biol. doi: 10.1186/1471-213X-10-76 contributor: fullname: Xie – volume: 140 start-page: 1111 year: 2013 ident: 2024053017562487100_DEV177790C24 article-title: Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis publication-title: Development doi: 10.1242/dev.080226 contributor: fullname: Liu – volume: 6 start-page: 171 year: 1962 ident: 2024053017562487100_DEV177790C33 article-title: The diaphragm of capillary endothelial fenestrations publication-title: J. Ultrastruct. Res. doi: 10.1016/S0022-5320(62)90052-7 contributor: fullname: Rhodin – volume: 425 start-page: 101 year: 2017 ident: 2024053017562487100_DEV177790C41 article-title: CNS angiogenesis and barriergenesis occur simultaneously publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2017.03.017 contributor: fullname: Umans – volume: 33 start-page: 5320 year: 2019 ident: 2024053017562487100_DEV177790C42 article-title: Expression patterns of endothelial permeability pathways in the development of the blood-retinal barrier in mice publication-title: FASEB J. doi: 10.1096/fj.201801499RRR contributor: fullname: van der Wijk – start-page: 301 volume-title: Molecular Neuroendocrinology year: 2016 ident: 2024053017562487100_DEV177790C43 article-title: Non mammalian models for neurohypophysial peptides doi: 10.1002/9781118760369.ch14 contributor: fullname: Wircer – volume: 12 start-page: 270 year: 1961 ident: 2024053017562487100_DEV177790C9 article-title: Fine structure and function in capillaries of the anterior pituitary gland publication-title: Angiology doi: 10.1177/000331976101200704 contributor: fullname: Farquhar – volume: 5 start-page: 1800338 year: 2018 ident: 2024053017562487100_DEV177790C14 article-title: The dual functional reflecting iris of the Zebrafish publication-title: Advanced Science doi: 10.1002/advs.201800338 contributor: fullname: Gur – volume: 37 start-page: 633 year: 1968 ident: 2024053017562487100_DEV177790C31 article-title: Structural modulations of plasmalemmal vesicles publication-title: J. Cell Biol. doi: 10.1083/jcb.37.3.633 contributor: fullname: Palade – volume: 17 start-page: 208 year: 1963 ident: 2024053017562487100_DEV177790C32 article-title: The use of lead citrate at high pH as an electron-opaque stain in electron microscopy publication-title: J. Cell Biol. doi: 10.1083/jcb.17.1.208 contributor: fullname: Reynolds – volume: 44 start-page: 401 year: 1986 ident: 2024053017562487100_DEV177790C12 article-title: Differences in function and structure of the capillary endothelium in the supraoptic nucleus and pituitary neural lobe of rats. Evidence for the supraoptic nucleus as an osmometer publication-title: Neuroendocrinology doi: 10.1159/000124678 contributor: fullname: Gross – volume: 138 start-page: 709 year: 2012 ident: 2024053017562487100_DEV177790C18 article-title: Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice publication-title: Histochem. Cell Biol. doi: 10.1007/s00418-012-0987-3 contributor: fullname: Herrnberger – volume: 100 start-page: 158 year: 2007 ident: 2024053017562487100_DEV177790C1 article-title: Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms publication-title: Circ. Res. doi: 10.1161/01.RES.0000255691.76142.4a contributor: fullname: Aird – volume: 150 start-page: 5509 year: 2009 ident: 2024053017562487100_DEV177790C5 article-title: Brain-endocrine interactions: a microvascular route in the mediobasal hypothalamus publication-title: Endocrinology doi: 10.1210/en.2009-0584 contributor: fullname: Ciofi – volume: 202 start-page: 325 year: 1995 ident: 2024053017562487100_DEV177790C16 article-title: Novel mouse endothelial cell surface marker is suppressed during differentiation of the blood brain barrier publication-title: Dev. Dyn. doi: 10.1002/aja.1002020402 contributor: fullname: Hallmann – volume: 15 start-page: 3615 year: 2004 ident: 2024053017562487100_DEV177790C39 article-title: PV1 is a key structural component for the formation of the stomatal and fenestral diaphragms publication-title: Mol. Biol. Cell doi: 10.1091/mbc.e03-08-0593 contributor: fullname: Stan – volume: 47 start-page: 711 year: 2018 ident: 2024053017562487100_DEV177790C2 article-title: Pituicyte cues regulate the development of permeable neuro-vascular interfaces publication-title: Dev. Cell doi: 10.1016/j.devcel.2018.10.017 contributor: fullname: Anbalagan – volume: 244 start-page: 493 year: 1986 ident: 2024053017562487100_DEV177790C27 article-title: The endothelial pocket: a new structure in fenestrated endothelia publication-title: Cell Tissue Res. doi: 10.1007/BF00212526 contributor: fullname: Milici – volume: 568 start-page: 193 year: 2019 ident: 2024053017562487100_DEV177790C6 article-title: Genetic compensation triggered by mutant mRNA degradation publication-title: Nature doi: 10.1038/s41586-019-1064-z contributor: fullname: El-Brolosy – volume: 31 start-page: 14835 year: 2011 ident: 2024053017562487100_DEV177790C3 article-title: The metabolic regulator PGC-1{alpha} directly controls the expression of the hypothalamic neuropeptide oxytocin publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1798-11.2011 contributor: fullname: Blechman – volume: 205 start-page: 491 year: 2008 ident: 2024053017562487100_DEV177790C25 article-title: VEGF and TGF-β are required for the maintenance of the choroid plexus and ependyma publication-title: J. Exp. Med. doi: 10.1084/jem.20072041 contributor: fullname: Maharaj – volume: 47 start-page: D351 year: 2018 ident: 2024053017562487100_DEV177790C28 article-title: InterPro in 2019: improving coverage, classification and access to protein sequence annotations publication-title: Nucleic Acids Res. doi: 10.1093/nar/gky1100 contributor: fullname: Mitchell – volume: 12 start-page: 1639 year: 2016 ident: 2024053017562487100_DEV177790C13 article-title: Plasmalemma vesicle-associated protein: a crucial component of vascular homeostasis publication-title: Exp. Ther. Med. doi: 10.3892/etm.2016.3557 contributor: fullname: Guo – volume: 23 start-page: 1203 year: 2012 ident: 2024053017562487100_DEV177790C40 article-title: The diaphragms of fenestrated endothelia: gatekeepers of vascular permeability and blood composition publication-title: Dev. Cell doi: 10.1016/j.devcel.2012.11.003 contributor: fullname: Stan – volume: 23 start-page: 920 year: 2019 ident: 2024053017562487100_DEV177790C17 article-title: Phorbol esters induce PLVAP expression via VEGF and additional secreted molecules in MEK1-dependent and p38, JNK and PI3K/Akt-independent manner publication-title: J. Cell. Mol. Med. doi: 10.1111/jcmm.13993 contributor: fullname: Hamilton – volume: 21 start-page: 642 year: 2011 ident: 2024053017562487100_DEV177790C15 article-title: The hypothalamic neuropeptide oxytocin is required for formation of the neurovascular interface of the pituitary publication-title: Dev. Cell doi: 10.1016/j.devcel.2011.09.004 contributor: fullname: Gutnick – volume: 8 start-page: 275 year: 2017 ident: 2024053017562487100_DEV177790C30 article-title: Advances in understanding of structural reorganization in the hypothalamic neurosecretory system publication-title: Front. Endocrinol. doi: 10.3389/fendo.2017.00275 contributor: fullname: Miyata – volume: 27 start-page: 422 year: 2000 ident: 2024053017562487100_DEV177790C11 article-title: Circumventricular organs: definition and role in the regulation of endocrine and autonomic function publication-title: Clin. Exp. Pharmacol. Physiol. doi: 10.1046/j.1440-1681.2000.03259.x contributor: fullname: Ganong – volume-title: The Pituitary Gland: A Comparative Account year: 1974 ident: 2024053017562487100_DEV177790C19 contributor: fullname: Holmes – volume: 119 start-page: 5060 year: 2018 ident: 2024053017562487100_DEV177790C10 article-title: The caveolar membrane system in endothelium: from cell signaling to vascular pathology publication-title: J. Cell. Biochem. doi: 10.1002/jcb.26793 contributor: fullname: Filippini |
| SSID | ssj0003677 |
| Score | 2.4297018 |
| Snippet | To maintain body homeostasis, endocrine systems must detect and integrate blood-borne peripheral signals. This is mediated by fenestrae, specialized permeable... |
| SourceID | pubmedcentral proquest crossref pubmed |
| SourceType | Open Access Repository Aggregation Database Index Database |
| Title | The fenestrae-associated protein Plvap regulates the rate of blood-borne protein passage into the hypophysis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/31740533 https://search.proquest.com/docview/2315972703 https://pubmed.ncbi.nlm.nih.gov/PMC6918783 |
| Volume | 146 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLbYEIgXBONWbjKCtyrQxK7tPCKWbUAZSOukiZfIcRy1UkmqtqnUf8_xJZcyHsYDL1HkWG7k7-vJufkchN5JyUMp2ThgmhvXjWKBZLoIYpKzXAkZUmlc2WcX_PxKHCc06ZLYu7H_ijSMAdbm5Ow_oN0uCgNwD5jDFVCH641xL4wA26ykDqTffW2qAVSms-Xwx2Irl8OV60FvCjyYHEPpsgVcGjvQotTt_CWsYRJ75qVXU2e7ZWUdIuu-ZtvLPrKR4eYsWM_VcAqGrgvyT-r813zR-QIWWs28K_aLLMv2wcUMqGSbTg2TnWyTQU5ry7Pj7XzV91qEtuXCyIld7SQtNbHj0L9DI4q9O9Jxzh1EvibjQakAEHK9fR9yUy2x-5I10fvz7-nJ5WSSTpOr6QG6HYEMstb256_tR5owzn21WljvQ7favn5yzej4M3e2p4xMH6D73orAHx38D9EtXR6hO66v6O4I3f3mMyZg8GdlBx-hBTAD_40Z2CONLTNwywwMYGPDDFwVuMeMdr5nBjbMsJM7ZjxGlyfJ9NNZ4HttBIrQaBOM4X9ZSKkjrSM-GmecUhpnipBCURFzGz5Q5hRzRFic8TATIiyiLBMs52ABKPIEHZZVqZ8hzAs6AqVbZVJoypgEwygO1ZhmIBYoUWqA3jY7nC5dSZXUmKKAQwo4pA6HAXrTbH4KEs-EsWSpq3qdgkUCVjC8JRmgpw6Mdh3Qhqk5XT5AfA-mdoKppr7_pJzPbFV1FoeCC_L8Br_7At3rOP0SHW5WtX6FDtZ5_dqy7Dc5o5ko |
| link.rule.ids | 230,315,782,786,887,27933,27934 |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+fenestrae-associated+protein+Plvap+regulates+the+rate+of+blood-borne+protein+passage+into+the+hypophysis&rft.jtitle=Development+%28Cambridge%29&rft.au=Gordon%2C+Ludmila&rft.au=Blechman%2C+Janna&rft.au=Shimoni%2C+Eyal&rft.au=Gur%2C+Dvir&rft.date=2019-12-02&rft.eissn=1477-9129&rft.volume=146&rft.issue=23&rft_id=info:doi/10.1242%2Fdev.177790&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0950-1991&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0950-1991&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0950-1991&client=summon |