MoS2 based nanomaterials: Advanced antibacterial agents for future

• Published in: Journal of controlled release Vol. 348; pp. 158 - 185
• Main Authors: Sethulekshmi, A.S., Saritha, Appukuttan, Joseph, Kuruvilla, Aprem, Abi Santhosh, Sisupal, Suja Bhargavan
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-08-2022
• Subjects: Antibacterial action; Functionalization; Hybrids; Molybdenum disulphide; MoS2 nanoflowers; MoS2 quantum dot; MoS2 nanoflowers; Antibacterial action; Hybrids; Functionalization; Molybdenum disulphide; MoS2 quantum dot
• ISSN: 0168-3659; 1873-4995
• DOI: 10.1016/j.jconrel.2022.05.047

Bacterial infections are yet another serious threat to human health. Misuse or overuse of conventional antibiotics has led to the arrival of various super resistant bacteria along with many serious side effects to human body. In this exigent circumstance, the use of nanomaterial based antibacterial agents is one of the most appropriate solutions to fight against bacteria thereby causing an inhibition to bacterial proliferation. Recent studies show that, due to the large surface area, high biocompatibility, strong near-infrared (NIR) absorption and low cytotoxicity, molybdenum disulphide (MoS2), an extraordinary member in the transition metal dichalcogenides (TMDs) is extensively explored in the obliteration of many drug resistant bacteria, photothermal therapy and drug delivery. MoS2 based nanomaterials can effectively prevent bacterial growth through many mechanisms. Through this review, we have tried to provide an inclusive knowledge on the recent progress of antibacterial studies in MoS2 based nanomaterials including MoS2 nanosheets, nanoflowers, quantum dot (QD), hybrid nanocomposites and polymer nanocomposites. Moreover, toxicity of MoS2 based nanomaterials is described at the end of the review.
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•This review summarizes the recent antibacterial studies in MoS2 based nanomaterials.•Various MoS2 based nanomaterials are discussed in this review.•Functionalization of MoS2 nanomaterials is also discussed in detail.•Antibacterial properties of various MoS2 based nanomaterials are described.•Toxicity of MoS2 based nanomaterials are also described in this review.