Proteomic Interrogation in Cancer Biomarker

• Published in: Advances in experimental medicine and biology Vol. 1187; p. 305
• Main Author: Kang, Un-Beom
• Format: Journal Article
• Language: English
• Published: United States 2021
• Subjects: Biomarkers - metabolism; Biomarkers, Tumor - genetics; Humans; Mass Spectrometry; Neoplasms - diagnosis; Neoplasms - genetics; Protein Processing, Post-Translational; Proteins; Proteomics; Biomarker; Proteogenomics; Clinical application; Proteomics; Cancer
• ISSN: 0065-2598
• DOI: 10.1007/978-981-32-9620-6_15

Biomarkers factor into the diagnosis and treatment of almost every patient with cancer. The innovation in proteomics follows improvement of mass spectrometry techniques and data processing strategy. Recently, proteomics and typical biological studies have been the answer for clinical applications. The clinical proteomics techniques are now actively adapted to protein identification in large patient cohort, biomarker development for more sensitive and specific screening based on quantitative data. And, it is important for clinical, translational researchers to be acutely aware of the issues surrounding appropriate biomarker development, in order to facilitate entry of clinically useful biomarkers into the clinic. Here, we discuss in detail include the case research for clinical proteomics. Furthermore, we give an overview on the current developments and novel findings in proteomics-based cancer biomarker research.