Modulation of ionotropic glutamate receptor channels

• Published in: Neurochemical research Vol. 26; no. 8-9; pp. 925 - 932
• Main Authors: KÖLES, L, WIRKNER, K, ILLES, P
• Format: Journal Article
• Language: English
• Published: New York, NY Springer 01-09-2001; Springer Nature B.V
• Subjects: Animals; Biological and medical sciences; Brain - metabolism; Central nervous system; Central neurotransmission. Neuromudulation. Pathways and receptors; Fundamental and applied biological sciences. Psychology; Ion Channels - metabolism; Ion Channels - physiology; Phosphorylation; Receptors, Glutamate - metabolism; Receptors, Glutamate - physiology; Vertebrates: nervous system and sense organs; A2A adenosine receptor; Ionotropic receptor; Phosphorylation; Glutamate receptor; Review; Central nervous system
• ISSN: 0364-3190; 1573-6903
• DOI: 10.1023/A:1012380416876

Glutamate is the major excitatory neurotransmitter in the brain. It acts at ligand-gated cationic channels (NMDA, AMPA and kainate receptors) and at G protein-coupled metabotropic glutamate receptors as well. The glutamatergic transmission is suggested to be involved in development, learning and memory. Its dysfunction can be detected in epilepsy, stroke, neurodegenerative disorders and drug abuse. This paper summarizes the present knowledge on the modulation of glutamate-gated ion channels in the central nervous system by phosphorylation. An inhibitory interaction between adenosine A2A receptors and NMDA receptors in the neostriatum is described as an example. mediated by the phospholipase C/inositol trisphosphate/calmodulin and calmodulin kinase II pathway.