High-flow nasal cannula oxygen therapy in infants with acute lower respiratory tract infection. An experience in hospitals of the City of Buenos Aires

• Published in: Archivos argentinos de pediatría Vol. 117; no. 5; pp. 286 - 293
• Main Authors: Monteverde, Ezequiel, Fernández, Analía, Ferrero, Fernando, Barbaro, Cristian, De Lillo, Leonardo, Lavitola, Mariana, Golubicki, Ariel
• Format: Journal Article
• Language: English
• Published: Argentina 01-10-2019
• Subjects: Argentina; Cannula; Female; Humans; Infant; Male; Oxygen Inhalation Therapy - adverse effects; Oxygen Inhalation Therapy - methods; Prospective Studies; Respiratory Tract Infections - therapy; Treatment Failure; Argentina; respiratory tract infections; respiratory insufficiency; bronchiolitis; oxygen therapy
• ISSN: 0325-0075; 1668-3501
• DOI: 10.5546/aap.2019.eng.286

During the winter, infants with acute lower respiratory tract infection (ALRTI) overburden health resources. In the Autonomous City of Buenos Aires, 35 000 children are seen at the hospitals every year; 8-10 % of them are admitted to the general hospitalization ward and 5-12 % of these, to the intensive care unit (ICU). In 2017, the Department of Maternal and Child Health of the Autonomous City of Buenos Aires included high flow nasal cannula (HNFC) oxygen therapy in the ALRTI protocol in the general ward of 3 hospitals. The objective of this study was to describe its outcomes and explore the potential factors related to therapeutic failure.
Prospective, descriptive study with infants < 18 months old hospitalized due to ALRTI in 3 hospitals (Durand, Elizalde, Gutiérrez) between June and September 2017. All children unable to comply with low-flow therapeutic targets received HNFC oxygen therapy; admission to the ICU was considered a failure.
Out of 522 patients hospitalized due to ALRTI, 39.7% required HNFC oxygen therapy. No significant baseline differences were observed between patients receiving HNFC and conventional oxygen therapy. Failure was observed in only 8.7% of patients with HNFC oxygen therapy. The decrease in respiratory rate was significantly greater and longer in patients with support success versus those with failure (p < 0.01). No complications were recorded.
The implementation of HNFC oxygen therapy under a protocol in the general wards was a safe measure. Patients with therapeutic failure showed a smaller reduction in respiratory rate during treatment.