Glucocorticoid regulation of growth hormone (GH) secretagogue-induced growth responses and GH secretagogue receptor expression in the rat

Synthetic GH-releasing peptides such as GHRP-6 are potent GH secretagogues (GHSs) in several species, but attempts to stimulate growth by continuous GHS exposure have had limited success. GHSs also release ACTH and adrenal steroids. Since glucocorticoid excess is associated with poor linear growth,...

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Bibliographic Details
Published in:	Growth hormone & IGF research Vol. 10; no. 1; pp. 45 - 52
Main Authors:	Thomas, G.B., Bennett, P.A., Carmignac, D.F., Robinson, I.C.A.F.
Format:	Journal Article
Language:	English
Published:	Scotland Elsevier Ltd 01-02-2000
Subjects:	Adrenal Glands - physiology Adrenalectomy Animals Blood Glucose - metabolism Body Weight - drug effects Cholesterol - blood Dexamethasone - pharmacology Female Glucocorticoids - physiology Growth Hormone - blood Growth Hormone - metabolism Hypothalamus - drug effects In Situ Hybridization Insulin - blood Key words: GH, secretagogue, receptor, adrenal, growth, dexamethasone Liver - drug effects Rats Receptors, Somatotropin - blood Receptors, Somatotropin - metabolism Time Factors Triglycerides - blood Key words: GH, secretagogue, receptor, adrenal, growth, dexamethasone
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