Concurrent acute lymphoblastic leukemia and juvenile pilocytic astrocytoma in a pediatric patient

• Published in: Journal of pediatric hematology/oncology Vol. 22; no. 5; pp. 451 - 453
• Main Authors: KIM, Amanda L, FERNANDEZ, Conrad V, GREER, Wenda L, HOGG, David, LASSAM, Norman J, RESCH, Lothar
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01-09-2000
• Subjects: Astrocytoma - complications; Biological and medical sciences; Child; Genes, p53; Hematologic and hematopoietic diseases; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Neoplasms, Second Primary - etiology; Neurology; Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications; Tumors of the nervous system. Phacomatoses; Human; Immunohistochemistry; Nervous system diseases; Process variant; Acute; Male; Malignant hemopathy; Case study; Pathology; Concomitant disease; Glioma; Lymphoproliferative syndrome; Central nervous system disease; Tumor; Clinical investigation; Acute lymphocytic leukemia; Child; Astrocytoma
• ISSN: 1077-4114; 1536-3678
• DOI: 10.1097/00043426-200009000-00013

The concurrence of acute lymphoblastic leukemia (ALL) and an asymptomatic juvenile pilocytic astrocytoma is described. A 6-year-old boy without clinical evidence of neurofibromatosis had a juvenile pilocytic astrocytoma diagnosed on radiologic examination and before treatment of acute pre-B cell lymphoblastic leukemia. The patient has had a partial resection of the astrocytoma and is 9 months into treatment of his ALL, which is in complete remission. p53 gene mutation was not identified in this patient. The concurrent diagnosis before treatment of ALL and juvenile pilocytic astrocytoma, the latter normally an indolent tumor, suggests that some cases of astrocytoma previously ascribed to radiotherapy or other treatment may in fact be caused by other factors.