First Experience of Clinical Application of LCZ696--an AT1-angiotensin Receptors and Neprilysin Inhibitor--in Patients With Chronic Heart Failure and Reduced Ejection Fraction

Simultaneous inhibition of the renin-angiotensin-aldosterone system and the system of degradation of natriuretic peptides can potentially provide unique therapeutic effects in patients with chronic heart failure (CHF) with reduced ejection fraction (EF). Aim of this study was to assess tolerability...

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Bibliographic Details
Published in:	Kardiologiia Vol. 55; no. 7; p. 14
Main Authors:	Kobalava, Zh D, Pavlikova, E P, Averkov, O A, Merai, I, Babaeva, L A, Amirbegishvili, I M, Kotovskaya, Yu V, Moisfev, V S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-2015
Subjects:	Aminobutyrates - administration & dosage Angiotensin II Type 1 Receptor Blockers - administration & dosage Dose-Response Relationship, Drug Drug Combinations Echocardiography, Doppler Female Follow-Up Studies Heart Failure - diagnostic imaging Heart Failure - drug therapy Heart Failure - physiopathology Humans Male Middle Aged Neprilysin - antagonists & inhibitors Stroke Volume - drug effects Stroke Volume - physiology Tetrazoles - administration & dosage Treatment Outcome
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