Synthesis of hybrid natural product analogues with anti-tumour properties

Synthesis of hybrid natural product analogues with anti-tumour properties

High yielding and diastereoselective conjugate addition reactions of a (−)-quinic acid derived enone have provided access to a small library of hybrid analogues of the anti-tumour natural products antheminone A and COTC. The novel compounds were assessed for their antiproliferative activities toward...

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Bibliographic Details
Published in:Tetrahedron Vol. 72; no. 35; pp. 5433 - 5443
Main Authors: Christou, Stephania, Edwards, Alyn C., Pritchard, Robin G., Quayle, Peter, Song, Yiwei, Stratford, Ian J., Williams, Katharine F., Whitehead, Roger C.
Format: Journal Article
Language:English
Published: Elsevier Ltd 01-09-2016
Subjects:
Anti-tumour
Catalysis
Conjugate addition
Natural product analogue
Rhodium
Transition metal
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Rhodium
Natural product analogue
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Anti-tumour
Conjugate addition
Transition metal
Catalysis
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Summary:High yielding and diastereoselective conjugate addition reactions of a (−)-quinic acid derived enone have provided access to a small library of hybrid analogues of the anti-tumour natural products antheminone A and COTC. The novel compounds were assessed for their antiproliferative activities towards the A549 non-small-cell lung cancer cell line revealing some useful structure-activity relationships. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2016.07.033