CD4+ T cells are not required for the induction of dengue virus-specific CD8+ T cell or antibody responses but contribute to protection after vaccination

The contribution of T cells to the host response to dengue virus (DENV) infection is not well understood. We previously demonstrated a protective role for CD8(+) T cells during primary DENV infection using a mouse-passaged DENV strain and IFN-α/βR(-/-) C57BL/6 mice, which are susceptible to DENV inf...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 185; no. 9; pp. 5405 - 5416
Main Authors:	Yauch, Lauren E, Prestwood, Tyler R, May, Monica M, Morar, Malika M, Zellweger, Raphaël M, Peters, Bjoern, Sette, Alessandro, Shresta, Sujan
Format:	Journal Article
Language:	English
Published:	United States 01-11-2010
Subjects:	Animals Antibodies, Viral - blood Antibodies, Viral - immunology Antigens, Viral - immunology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Dengue - blood Dengue - immunology Dengue Vaccines - immunology Dengue Virus - immunology Enzyme-Linked Immunosorbent Assay Epitopes, T-Lymphocyte - immunology Flow Cytometry Immunohistochemistry Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Mice, Knockout Viral Load
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