Conformation of the Glycosidic Linkage in a Disaccharide Investigated by Double-Quantum Solid-State NMR

Conformation of the Glycosidic Linkage in a Disaccharide Investigated by Double-Quantum Solid-State NMR

Double-quantum heteronuclear local field NMR is performed on a sample of a 13C2-labeled disaccharide, in which the two 13C spins are located on opposite sides of the glycosidic linkage. The evolution of the double-quantum coherences is found to be consistent with the solid-state conformation of the...

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Bibliographic Details
Published in:Journal of magnetic resonance (1997) Vol. 151; no. 1; pp. 136 - 141
Main Authors: Ravindranathan, S., Karlsson, T., Lycknert, K., Widmalm, G., Levitt, M.H.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-07-2001
Subjects:
Carbohydrate Conformation
Carbohydrate Sequence
Computer Simulation
Disaccharides - chemistry
Glycosides - chemistry
Magnetic Resonance Spectroscopy
Molecular Sequence Data
carbohydrates
Moleculix
trehalose
double-quantum NMR
glycosidic linkage
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Summary:Double-quantum heteronuclear local field NMR is performed on a sample of a 13C2-labeled disaccharide, in which the two 13C spins are located on opposite sides of the glycosidic linkage. The evolution of the double-quantum coherences is found to be consistent with the solid-state conformation of the molecule, as previously determined by X-ray diffraction. The dependence of the double-quantum evolution on the glycosidic torsional angles is examined by using a graphical molecular manipulation program interfaced to a numerical spin simulation module.
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content type line 23
ISSN:1090-7807
1096-0856
DOI:10.1006/jmre.2001.2357