Vinflunine Oral Pharmacokinetics and Absolute Bioavailability of Soft and Hard Gelatin Capsules Results of Two Phase I Trials

Background: Vinflunine is a new-generation microtubule inhibitor, which is currently registered in Europe and in some countries elsewhere as an intravenous formulation for the second-line treatment of transitional urothelial cell carcinoma. On the basis of favourable non-clinical results, the clinic...

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Bibliographic Details
Published in:	Clinical pharmacokinetics Vol. 51; no. 6; pp. 357 - 364
Main Authors:	Delord, Jean-Pierre, Bennouna, Jaafar, Mourey, Loïc, Bougaret, Joël, Brandely-Talbot, Maud, Ferré, Pierre
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-06-2012 Adis International
Subjects:	Administration, Oral Adolescent Adult Aged Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Agents, Phytogenic - pharmacokinetics Biological and medical sciences Biological Availability Capsules - pharmacokinetics Cross-Over Studies Female Gelatin General pharmacology Humans Injections, Intravenous Internal Medicine Male Medical sciences Medicine Medicine & Public Health Middle Aged Neoplasms - drug therapy Original Research Article Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacotherapy Vinblastine - administration & dosage Vinblastine - adverse effects Vinblastine - analogs & derivatives Vinblastine - pharmacokinetics Transitional Cell Carcinoma Oral Chemotherapy Absolute Bioavailability Catharanthine Vinorelbine Antineoplastic agent Human Gelatin Oral administration Dosage form Phase I trial Hard capsule Bioavailability Pharmacokinetics Vinflunine
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