Inhibitory effect of caerulein on salivary secretion in man

Previous works have documented that pentagastrin has a stimulatory effect on salivary secretion. In this paper, we have studied the action of caerulein, a peptide that has an active gastrin-like terminal tetrapeptide, on salivary secretion in man. Our data documented that caerulein and pentagastrin...

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Bibliographic Details
Published in:	Digestion Vol. 48; no. 3; p. 128
Main Authors:	Loguercio, C, Costato, D, Del Vecchio Blanco, C
Format:	Journal Article
Language:	English
Published:	Switzerland 1991
Subjects:	Adult Amylases - secretion Ceruletide - administration & dosage Ceruletide - pharmacology Gastric Juice - secretion Humans Male Papaverine - pharmacology Pentagastrin - pharmacology Salivary Glands - drug effects Salivation - drug effects Stimulation, Chemical
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Summary:	Previous works have documented that pentagastrin has a stimulatory effect on salivary secretion. In this paper, we have studied the action of caerulein, a peptide that has an active gastrin-like terminal tetrapeptide, on salivary secretion in man. Our data documented that caerulein and pentagastrin have similar excitatory effect on gastric secretion in man, but different actions on salivary flow. Caerulein, at increasing doses, inhibits salivary flow, but not the secretion of amylase; this effect is statistically significant at 0.5 micrograms/kg/h which is the same dose that maximally stimulates gastric secretion. The inhibitory effect of caerulein was not reversed by previous injection of papaverin.
ISSN:	0012-2823
DOI:	10.1159/000200684