Novel multi-component syntheses of pyrimidines using β-CD in aqueous medium

• Published in: Tetrahedron letters Vol. 57; no. 15; pp. 1656 - 1660
• Main Authors: Rakhi, Chowrasia, Ramesh, Katla, Darbem, Mariana P., Branquinho, Tabata A., de Oliveira, Aline Rufino, Manjari, Padma Sunitha, Domingues, Nelson Luís C.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 13-04-2016
• Subjects: 1,3-Dicarbonyl compounds; Aldehydes; Ammonium acetate; Catalysts; Derivatives; Economics; Pyrimidines; Tetrahedrons; Water; β-Cyclodextrin; Water; β-Cyclodextrin; Pyrimidines; Ammonium acetate; Aldehydes; 1,3-Dicarbonyl compounds
• ISSN: 0040-4039; 1873-3581
• DOI: 10.1016/j.tetlet.2016.02.106

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•Novel multi-component syntheses of pyrimidines developed for the first time using β-CD in aqueous medium.•The β-cyclodextrin is recyclable, inexpensive, economically-viable, non-toxic, and readily available.•Multi-component reactions (MCRs), green synthesis, and short reaction times for the synthesis of pyrimidines.
Using β-cyclodextrin (β-CD) as a catalyst pyrimidine derivatives were synthesized for the first time in aqueous medium. β-CD is a recyclable, inexpensive, economically viable, non-toxic, and readily available material. Various aldehydes were used with ammonium acetate, and 1,3-diketones to generate a series of pyrimidine derivatives in good to excellent yields.