Formal synthesis of (+)-crocacin C

The formal synthesis of (+)-crocacin C is reported. The approach described takes advantage of a highly regioselective epoxide cuprate addition and a diastereoselective Overman rearrangement. The synthesis is practical and amenable to scale up.

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Published in:Tetrahedron letters Vol. 53; no. 16; pp. 2114 - 2116
Main Authors: Pasqua, Adele E., Ferrari, Frank D., Crawford, James J., Marquez, Rodolfo
Format: Journal Article
Language:English
Published: Elsevier Ltd 18-04-2012
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Abstract The formal synthesis of (+)-crocacin C is reported. The approach described takes advantage of a highly regioselective epoxide cuprate addition and a diastereoselective Overman rearrangement. The synthesis is practical and amenable to scale up.
AbstractList The formal synthesis of (+)-crocacin C is reported. The approach described takes advantage of a highly regioselective epoxide cuprate addition and a diastereoselective Overman rearrangement. The synthesis is practical and amenable to scale up.
Author Marquez, Rodolfo
Pasqua, Adele E.
Ferrari, Frank D.
Crawford, James J.
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Crocacins
Overman rearrangement
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Snippet The formal synthesis of (+)-crocacin C is reported. The approach described takes advantage of a highly regioselective epoxide cuprate addition and a...
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Publisher
StartPage 2114
SubjectTerms COPPER OXIDE
Crocacins
Cuprates
FABRICATION
Formal synthesis
Overman rearrangement
Synthesis (chemistry)
Tetrahedrons
Title Formal synthesis of (+)-crocacin C
URI https://dx.doi.org/10.1016/j.tetlet.2012.02.049
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Volume 53
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