Formal synthesis of (+)-crocacin C
The formal synthesis of (+)-crocacin C is reported. The approach described takes advantage of a highly regioselective epoxide cuprate addition and a diastereoselective Overman rearrangement. The synthesis is practical and amenable to scale up.
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Published in: | Tetrahedron letters Vol. 53; no. 16; pp. 2114 - 2116 |
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Abstract | The formal synthesis of (+)-crocacin C is reported. The approach described takes advantage of a highly regioselective epoxide cuprate addition and a diastereoselective Overman rearrangement. The synthesis is practical and amenable to scale up. |
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AbstractList | The formal synthesis of (+)-crocacin C is reported. The approach described takes advantage of a highly regioselective epoxide cuprate addition and a diastereoselective Overman rearrangement. The synthesis is practical and amenable to scale up. |
Author | Marquez, Rodolfo Pasqua, Adele E. Ferrari, Frank D. Crawford, James J. |
Author_xml | – sequence: 1 givenname: Adele E. surname: Pasqua fullname: Pasqua, Adele E. organization: WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK – sequence: 2 givenname: Frank D. surname: Ferrari fullname: Ferrari, Frank D. organization: WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK – sequence: 3 givenname: James J. surname: Crawford fullname: Crawford, James J. organization: Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA – sequence: 4 givenname: Rodolfo surname: Marquez fullname: Marquez, Rodolfo email: rudi.marquez@glasgow.ac.uk, r.marquez@chem.gla.ac.uk organization: WestCHEM School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK |
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SubjectTerms | COPPER OXIDE Crocacins Cuprates FABRICATION Formal synthesis Overman rearrangement Synthesis (chemistry) Tetrahedrons |
Title | Formal synthesis of (+)-crocacin C |
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