Formal synthesis of (+)-crocacin C

Formal synthesis of (+)-crocacin C

The formal synthesis of (+)-crocacin C is reported. The approach described takes advantage of a highly regioselective epoxide cuprate addition and a diastereoselective Overman rearrangement. The synthesis is practical and amenable to scale up.

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Bibliographic Details
Published in:Tetrahedron letters Vol. 53; no. 16; pp. 2114 - 2116
Main Authors: Pasqua, Adele E., Ferrari, Frank D., Crawford, James J., Marquez, Rodolfo
Format: Journal Article
Language:English
Published: Elsevier Ltd 18-04-2012
Subjects:
COPPER OXIDE
Crocacins
Cuprates
FABRICATION
Formal synthesis
Overman rearrangement
Synthesis (chemistry)
Tetrahedrons
Formal synthesis
Crocacins
Overman rearrangement
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Description
Summary:The formal synthesis of (+)-crocacin C is reported. The approach described takes advantage of a highly regioselective epoxide cuprate addition and a diastereoselective Overman rearrangement. The synthesis is practical and amenable to scale up.
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ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.02.049