Initial treatment of seizures in children in an emergency department in rural Japan

• Published in: Brain & development (Tokyo. 1979) Vol. 43; no. 2; pp. 288 - 293
• Main Authors: Shiraki, Anna, Yasui, Masahiro, Kidokoro, Hiroyuki, Kido, Shinji, Ando, Hideo, Takahashi, Yoshiyuki, Natsume, Jun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-02-2021
• Subjects: Diazepam suppositories; Non-intravenous benzodiazepines; Non-pediatricians; Non-intravenous benzodiazepines; Non-pediatricians; Diazepam suppositories
• ISSN: 0387-7604; 1872-7131
• DOI: 10.1016/j.braindev.2020.08.004

Although the initial treatment of childhood seizures is important, treatment within an appropriate time window is often difficult in resource-limited areas. This study examined childhood seizure treatment in a rural area in Japan.
We retrospectively investigated children presenting to Nakatsugawa Municipal General Hospital emergency department between 2015 and 2018. From the hospital database, we identified children who were diagnosed with seizures, epilepsy, or acute infectious encephalitis/encephalopathy or were given benzodiazepines. We considered etiology, seizure duration, and treatment according to the specialties of the doctors providing initial care.
We extracted 236 seizure events: 40 initially treated by pediatricians, 16 by a mobile doctor team, and 180 by other doctors. Twenty patients had continuous seizures for longer than 5 min on admission. Two were treated by pediatricians at presentation; it took 4 and 7 min after arrival to stop the seizures. Four were treated by a mobile team, and 14 by other doctors; the median response times were 11.5 (range 3–47) and 19 (range 5–60) min, respectively. All patients treated by pediatricians or mobile doctor teams received intravenous or intramuscular diazepam, whereas 50% of those treated by other doctors initially received diazepam suppositories. In three of the 20 events, establishing intravenous access was difficult.
In rural Japan, many children with seizures are initially treated by doctors other than pediatricians or emergency physicians, and they require a longer time to achieve seizure cessation. Non-intravenous benzodiazepine formulas, which have not yet been approved in Japan, would be helpful.