Ligneous conjunctivitis: Fresh-frozen plasma and heparin use intra-and postoperatively, a report of two cases

• Published in: Arquivos brasileiros de oftalmologia Vol. 87; no. 2; p. e20220288
• Main Authors: Almeida, Isabela Costa Guerra Barreto de, Marback, Patrícia Maria Fernandes
• Format: Journal Article
• Language: English
• Published: Brazil Conselho Brasileiro de Oftalmologia 2024
• Subjects: Conjunctivitis - drug therapy; Conjunctivitis - surgery; Heparin - therapeutic use; Humans; OPHTHALMOLOGY; Plasminogen - deficiency; Skin Diseases, Genetic - complications; Skin Diseases, Genetic - therapy; Administration; Plasm; ophthalmic; Ophthalmic solutions; Conjunctivitis; Heparin; Plasminogen
• ISSN: 0004-2749; 1678-2925; 1678-2925
• DOI: 10.5935/0004-2749.2022-0288

Ligneous conjunctivitis is a rare chronic form of recurrent membranous inflammation and plasminogen deficiency. Ocular manifestations may be associated with sites other than mucous membranes, such as the oral cavity, internal ear, respiratory, genitals, and kidney. Treatment is extremely difficult because of the lack of topic plasminogen drops, and a high volume is required for systemic supplementation. This report aimed to present two patients with ligneous conjunctivitis treated with membrane excision, topical fresh-frozen plasma, and heparin intra-, and postoperatively. No recurrence was found in the ligneous membrane in the 12-month follow-up. The use of topical fresh-frozen plasma and heparin after membrane excision could be effective to avoid recurrence.