Hemodynamic insult by vascular risk factors and pharmacologic erection in men with erectile dysfunction : Doppler sonography study

• Published in: World journal of urology Vol. 18; no. 6; pp. 427 - 430
• Main Authors: Chung, W S, Shim, B S, Park, Y Y
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01-12-2000; Berlin Springer Nature B.V; New York, NY
• Subjects: Adolescent; Adult; Aged; Alcohol Drinking - adverse effects; Arteries - physiopathology; Biological and medical sciences; Blood Vessels - diagnostic imaging; Blood Vessels - physiopathology; Cavernous Sinus - physiopathology; Diabetes Complications; Drug therapy; Erectile Dysfunction - complications; Erectile Dysfunction - diagnostic imaging; Erectile Dysfunction - physiopathology; Genital system. Mammary gland; Health risk assessment; Hemodynamics; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Men; Middle Aged; Penis - blood supply; Penis - diagnostic imaging; Risk Factors; Smoking - adverse effects; Ultrasonic investigative techniques; Ultrasonography, Doppler, Color; Ultrasonography, Doppler, Duplex; Vascular Diseases - etiology; Sonography; Human; Erection disorders; Impotence; Etiopathogenesis; Tobacco smoking; Cardiovascular disease; Exploration; Male; Duplex ultrasonography; Penis; Risk factor; Medical imagery; Adult; Hemodynamics; Male genital diseases
• ISSN: 0724-4983; 1433-8726
• DOI: 10.1007/pl00007085

To evaluate the penodynamic impact of known vascular risk factors in men with erectile dysfunction, we obtained thorough medical histories covering diabetes, hypertension, heart disease and hypercholesterolemia, alcohol ingestion, and smoking in 265 consecutive patients. We also measured their penile hemodynamic parameters by color duplex ultrasonography after intracavernous prostaglandin E1 injection. In patients with vascular risk factors there was a statistically significant decrease in the peak systolic velocity and increase in the end-diastolic velocity of the cavernosal artery (P < 0.01). Those men who had diabetes had higher average end-diastolic velocities and lower resistance indices (P < 0.01). Smoking and alcohol use also affected penile hemodynamics (P < 0.05). These data confirm that vascular risk factors do increase the likelihood of vasculogenic impotence and that diabetes plays a major role in veno-occlusive dysfunction in the penis.