Solid-state ion sensors with a liquid junction-free polymer membrane-based reference electrode for blood analysis

• Published in: Sensors and actuators. B, Chemical Vol. 64; no. 1; pp. 8 - 14
• Main Authors: Yoon, Hyo Jung, Shin, Jae Ho, Lee, Sung Dong, Nam, Hakhyun, Cha, Geun Sig, Strong, Timothy D, Brown, Richard B
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 10-06-2000
• Subjects: All-solid-state ion sensors; Blood; Electrolytes; Ion selective electrodes; Ion selective membranes; Ion-selective electrode; Liquid junction-free reference electrode; Miniaturized ion sensors; Polyurethane-based ion-selective membranes; Polyurethanes; Solid state devices; Polyurethane-based ion-selective membranes; All-solid-state ion sensors; Ion-selective electrode; Miniaturized ion sensors; Liquid junction-free reference electrode
• ISSN: 0925-4005; 1873-3077
• DOI: 10.1016/S0925-4005(99)00476-1

A set of ion-selective membranes for the measurement of clinically relevant electrolytes, i.e., K
+, Na
+, Ca
2+, H
+ and Cl
−, and a solvent-processible polyurethane (PU)-based reference membrane were cast on metal electrodes patterned on small ceramic plates, and on silicon-based sensors. Since the liquid junction-free PU membrane-based reference electrode provides a constant potentiometric signal for an extended period of time, accurate determination of blood electrolytes could be made without using a separate reference flow. The PU membrane-based reference electrodes not only improve the mass producibility of miniaturized solid-state ion sensors but also simplify the configuration of flow cell cartridges without compromising their analytical performance.