Effects of feeding various tocotrienol sources on plasma lipids and aortic atherosclerotic lesions in cholesterol-fed rabbits
Tocotrienols exert hypocholesterolaemic and antioxidant effects, and may hence have anti-atherogenic properties. Therefore, the aim of this study was to investigate the cholesterol-lowering and anti-atherogenic effects of tocotrienols in cholesterol-fed rabbits. Rabbits were fed a basal diet (contro...
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| Published in: | Food research international Vol. 35; no. 2-3; pp. 245 - 251 |
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| Abstract | Tocotrienols exert hypocholesterolaemic and antioxidant effects, and may hence have anti-atherogenic properties. Therefore, the aim of this study was to investigate the cholesterol-lowering and anti-atherogenic effects of tocotrienols in cholesterol-fed rabbits. Rabbits were fed a basal diet (control) supplemented with γ-tocotrienol, γ-tocotrienyl acetate, mixed tocotrienols or α-tocotrienol for 12 weeks. All treatments resulted in significant increases in plasma tocotrienols. None of the treatments, however, had significant effects on serum lipids or size of atherosclerotic lesions. A trend towards a decrease in plasma cholesterol was observed following γ-tocotrienol treatment (−22%) after 6 weeks. The decrease was mainly attributable to a reduction in LDL cholesterol (23%), whereas HDL cholesterol increased (14%). This trend was mirrored in a non-significant reduction in lesion area (20%). Our results demonstrate that tocotrienols are absorbed, but have little effect on plasma lipids and atherosclerosis in cholesterol-fed rabbits. |
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| AbstractList | Tocotrienols exert hypocholesterolaemic and antioxidant effects, and may hence have anti-atherogenic properties. Therefore, the aim of this study was to investigate the cholesterol-lowering and anti-atherogenic effects of tocotrienols in cholesterol-fed rabbits. Rabbits were fed a basal diet (control) supplemented with γ-tocotrienol, γ-tocotrienyl acetate, mixed tocotrienols or α-tocotrienol for 12 weeks. All treatments resulted in significant increases in plasma tocotrienols. None of the treatments, however, had significant effects on serum lipids or size of atherosclerotic lesions. A trend towards a decrease in plasma cholesterol was observed following γ-tocotrienol treatment (−22%) after 6 weeks. The decrease was mainly attributable to a reduction in LDL cholesterol (23%), whereas HDL cholesterol increased (14%). This trend was mirrored in a non-significant reduction in lesion area (20%). Our results demonstrate that tocotrienols are absorbed, but have little effect on plasma lipids and atherosclerosis in cholesterol-fed rabbits. |
| Author | Baldenius, Kai Krämer, Klaus Nowakowsky, Brigitte Oberfrank, Uwe Hasselwander, Oliver Bahnemann, Rainer Schröder, Hartwig Kaufmann, Wolfgang Hoppe, Peter P |
| Author_xml | – sequence: 1 givenname: Oliver surname: Hasselwander fullname: Hasselwander, Oliver email: oliver.hasselwander@basf-ag.de – sequence: 2 givenname: Klaus surname: Krämer fullname: Krämer, Klaus – sequence: 3 givenname: Peter P surname: Hoppe fullname: Hoppe, Peter P – sequence: 4 givenname: Uwe surname: Oberfrank fullname: Oberfrank, Uwe – sequence: 5 givenname: Kai surname: Baldenius fullname: Baldenius, Kai – sequence: 6 givenname: Hartwig surname: Schröder fullname: Schröder, Hartwig – sequence: 7 givenname: Wolfgang surname: Kaufmann fullname: Kaufmann, Wolfgang – sequence: 8 givenname: Rainer surname: Bahnemann fullname: Bahnemann, Rainer – sequence: 9 givenname: Brigitte surname: Nowakowsky fullname: Nowakowsky, Brigitte |
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| CitedBy_id | crossref_primary_10_3923_ijp_2010_561_568 crossref_primary_10_1007_s11745_006_5119_1 crossref_primary_10_3923_ijom_2011_1_14 crossref_primary_10_1016_j_meatsci_2003_12_004 crossref_primary_10_1080_87559120802303840 crossref_primary_10_3923_ajava_2012_225_234 crossref_primary_10_3923_ajft_2012_168_172 |
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| Keywords | Lipids Tocotrienols Plasma cholesterol Atherosclerosis Nutrition Rat Cholesterolemia Rodentia Vitamin Cardiovascular disease Cholesterol LDL Supplemented diet E-Vitamins Antioxidant Biological activity Feeding Prevention Vertebrata Mammalia Absorption Cholesterol HDL |
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| SubjectTerms | Atherosclerosis Biological and medical sciences Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology General pharmacology Lipids Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plasma cholesterol Tocotrienols Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| Title | Effects of feeding various tocotrienol sources on plasma lipids and aortic atherosclerotic lesions in cholesterol-fed rabbits |
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