Perioperative Pain Relief by a COX-2 Inhibitor Affects Ileal Repair and Provides a Model for Anastomotic Leakage in the Intestine

The authors examined the potential of the cyclooxygenase 2 (COX-2) inhibitor carprofen to reproducibly induce anastomotic leakage. In experiment 1, an anastomosis was constructed in both ileum and colon of 20 rats, and they were given carprofen (5 mg/kg subcutaneously every 24 hours) or buprenorphin...

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Bibliographic Details
Published in:	Surgical innovation Vol. 20; no. 2; pp. 113 - 118
Main Authors:	van der Vijver, R. J., van Laarhoven, C. J. H. M., de Man, B. M., Lomme, R. M. L. M., Hendriks, T.
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA SAGE Publications 01-04-2013
Subjects:	Analgesics, Opioid - pharmacology Anastomotic Leak - chemically induced Anastomotic Leak - pathology Anastomotic Leak - physiopathology Animals Buprenorphine - pharmacology Carbazoles - adverse effects Carbazoles - pharmacology Collagen - metabolism Cyclooxygenase 2 Inhibitors - adverse effects Cyclooxygenase 2 Inhibitors - pharmacology Disease Models, Animal Ileum - drug effects Ileum - metabolism Ileum - physiopathology Ileum - surgery Male Matrix Metalloproteinase 2 - metabolism Pain - drug therapy Perioperative Period Pressure Rats Rats, Wistar Surgical Wound Dehiscence - chemically induced Weight Loss - drug effects colorectal surgery simulation surgical education
Online Access:	Get full text
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