Perioperative Pain Relief by a COX-2 Inhibitor Affects Ileal Repair and Provides a Model for Anastomotic Leakage in the Intestine
The authors examined the potential of the cyclooxygenase 2 (COX-2) inhibitor carprofen to reproducibly induce anastomotic leakage. In experiment 1, an anastomosis was constructed in both ileum and colon of 20 rats, and they were given carprofen (5 mg/kg subcutaneously every 24 hours) or buprenorphin...
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| Published in: | Surgical innovation Vol. 20; no. 2; pp. 113 - 118 |
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01-04-2013
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| Abstract | The authors examined the potential of the cyclooxygenase 2 (COX-2) inhibitor carprofen to reproducibly induce anastomotic leakage. In experiment 1, an anastomosis was constructed in both ileum and colon of 20 rats, and they were given carprofen (5 mg/kg subcutaneously every 24 hours) or buprenorphine (0.02 mg/kg subcutaneously every 12 hours). In another 20 rats an anastomosis was constructed in either ileum or colon, and all received carprofen (experiment 2). Animals were sacrificed after 3 days. In experiment 1, the ileal dehiscence rate was 60% in the carprofen group and 0% in the buprenorphine group (P = .0108). Colonic anastomoses in both groups remained patent. In experiment 2, the anastomotic leakage rate was 80% in ileum and 0% in colon. Thus, COX-2 inhibitors can severely interfere with intestinal healing, particularly in the ileum. Perioperative administration of carprofen yields a unique model for anastomotic leakage, which allows translational research on the effectiveness of perisuture line reinforcement. |
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| AbstractList | The authors examined the potential of the cyclooxygenase 2 (COX-2) inhibitor carprofen to reproducibly induce anastomotic leakage. In experiment 1, an anastomosis was constructed in both ileum and colon of 20 rats, and they were given carprofen (5 mg/kg subcutaneously every 24 hours) or buprenorphine (0.02 mg/kg subcutaneously every 12 hours). In another 20 rats an anastomosis was constructed in either ileum or colon, and all received carprofen (experiment 2). Animals were sacrificed after 3 days. In experiment 1, the ileal dehiscence rate was 60% in the carprofen group and 0% in the buprenorphine group ( P = .0108). Colonic anastomoses in both groups remained patent. In experiment 2, the anastomotic leakage rate was 80% in ileum and 0% in colon. Thus, COX-2 inhibitors can severely interfere with intestinal healing, particularly in the ileum. Perioperative administration of carprofen yields a unique model for anastomotic leakage, which allows translational research on the effectiveness of perisuture line reinforcement. |
| Author | de Man, B. M. van der Vijver, R. J. van Laarhoven, C. J. H. M. Lomme, R. M. L. M. Hendriks, T. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22532618$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_jchirv_2016_03_016 crossref_primary_10_1007_s00384_013_1652_6 crossref_primary_10_15406_jaccoa_2015_03_00107 crossref_primary_10_1007_s00464_018_6355_1 crossref_primary_10_1016_j_jss_2017_11_012 crossref_primary_10_1016_j_jviscsurg_2016_06_011 crossref_primary_10_1089_sur_2016_086 crossref_primary_10_1007_s11605_015_2874_4 crossref_primary_10_1016_j_jss_2014_08_047 crossref_primary_10_1007_s00268_014_2531_1 crossref_primary_10_1016_j_jss_2014_05_085 crossref_primary_10_1097_ALN_0000000000004141 crossref_primary_10_1186_s12876_015_0410_3 crossref_primary_10_1016_j_gassur_2024_06_016 |
| Cites_doi | 10.1177/155335060501200304 10.1002/bjs.4722 10.1002/bjs.5288 10.1159/000096975 10.4049/jimmunol.1101186 10.1007/BF02090163 10.1007/s00268-001-0256-4 10.1046/j.0007-1323.2001.01829.x 10.1007/s10350-005-0142-5 10.1038/laban0311-85 10.1016/j.rvsc.2009.11.002 10.1016/j.cca.2009.12.026 10.1002/bjs.6598 10.1016/j.amjsurg.2010.09.022 10.1007/s10585-009-9241-3 10.1007/s00268-009-0252-7 10.1111/j.1365-2885.2004.00618.x 10.1038/bjc.1995.355 10.1016/j.pain.2008.04.014 10.1080/01926230590906512 10.1097/01.sla.0000225083.27182.85 10.2460/ajvr.2004.65.810 10.1006/jsre.1993.1137 10.1016/j.jss.2008.08.019 10.1016/j.jamcollsurg.2008.10.015 10.1007/DCR.0b013e3181dcee11 |
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| SubjectTerms | Analgesics, Opioid - pharmacology Anastomotic Leak - chemically induced Anastomotic Leak - pathology Anastomotic Leak - physiopathology Animals Buprenorphine - pharmacology Carbazoles - adverse effects Carbazoles - pharmacology Collagen - metabolism Cyclooxygenase 2 Inhibitors - adverse effects Cyclooxygenase 2 Inhibitors - pharmacology Disease Models, Animal Ileum - drug effects Ileum - metabolism Ileum - physiopathology Ileum - surgery Male Matrix Metalloproteinase 2 - metabolism Pain - drug therapy Perioperative Period Pressure Rats Rats, Wistar Surgical Wound Dehiscence - chemically induced Weight Loss - drug effects |
| Title | Perioperative Pain Relief by a COX-2 Inhibitor Affects Ileal Repair and Provides a Model for Anastomotic Leakage in the Intestine |
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