A comparative study of effect of oral chronic cyanide administration on some rabbit tissue ATPases

• Published in: Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology Vol. 109; no. 2; p. 215
• Main Authors: Okolie, N P, Onoagbe, I O, Aisien, F A
• Format: Journal Article
• Language: English
• Published: United States 01-10-1994
• Subjects: Administration, Oral; Animals; Ca(2+) Mg(2+)-ATPase - antagonists & inhibitors; Calcium-Transporting ATPases - antagonists & inhibitors; Kidney - enzymology; Liver - enzymology; Male; Potassium Cyanide - administration & dosage; Potassium Cyanide - toxicity; Rabbits; Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors
• ISSN: 1367-8280
• DOI: 10.1016/0742-8413(94)00027-8

The effect of oral KCN administration on Na(+)-K(+)-ATPase, Ca(2+)-ATPase and Mg(2+)-ATPase activities was studied in some rabbit tissues. Generally, the order of activity of the enzymes was kidney > liver > ileum > colon. There were significant decreases (P < 0.05) in the activities of all the ATPases in the tissues of KCN-treated rabbits relative to controls. The decreases in Na(+)-K(+)-ATPase and Ca(2+)-ATPase activities were most pronounced in liver and kidney. The decreases in ATPases suggest impairment of membrane function as a result of the toxic effect of cyanide.