Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors

[Display omitted] To investigate the contribution of hydrogen bonding between the 14-hydroxy group and the 6-amide chain on the binding affinity of nalfurafine toward KOR and OX1R, we prepared the 14-H and 14-dehydrated nalfurafine and their five-membered D-ring nalfurafine (D-nor-nalfurafine) deriv...

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Bibliographic Details

Published in:	Bioorganic & medicinal chemistry letters Vol. 59; p. 128527
Main Authors:	Katoh, Koki, Yamamoto, Naoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Tanimura, Ryuji, Saitoh, Tsuyoshi, Nagumo, Yasuyuki, Kutsumura, Noriki, Yanagisawa, Masashi, Nagase, Hiroshi
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-03-2022
Subjects:	14-dehydration nalfurafine 14-H nalfurafine D-nor-nalfurafine KOR Structure-activity relationship 14-H nalfurafine D-nor-nalfurafine 14-dehydration nalfurafine Structure-activity relationship KOR
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