Skin permeability data: anomalous results

Analysis of published skin permeation data has shown that a few compounds appear to have anomalous skin permeability coefficients. These include penetrants such as naproxen, atropine and nicotine. The permeabilities of these materials were re-determined together with aspirin, benzoic acid, diclofena...

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Bibliographic Details
Published in:	International journal of pharmaceutics Vol. 170; no. 1; pp. 129 - 133
Main Authors:	Degim, I.Tuncer, Pugh, W.John, Hadgraft, Jonathan
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01-08-1998 Elsevier
Subjects:	Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents General pharmacology Medical sciences Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Prediction Skin absorption Skin permeability Transdermal Skin absorption Skin permeability Transdermal Prediction Benzoic acid Partition coefficient Acetylsalicylic acid Permeability In vitro Diclofenac Parasympathomimetic Non steroidal antiinflammatory agent Absorption Arylacetic acid derivatives Naproxen Ibuprofen Atropine Skin Salicylates Antidote Diffusion
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Summary:	Analysis of published skin permeation data has shown that a few compounds appear to have anomalous skin permeability coefficients. These include penetrants such as naproxen, atropine and nicotine. The permeabilities of these materials were re-determined together with aspirin, benzoic acid, diclofenac, ibuprofen and methyl nicotinate. The results are discussed in conjunction with published regression analyses and compared with values predicted by estimating the octanol–water partition coefficients using commercial software packages.
ISSN:	0378-5173 1873-3476
DOI:	10.1016/S0378-5173(98)00113-6