Modulating effects of steviol and steviol glycosides on adipogenesis, lipogenesis, glucose uptake and insulin resistance in 3T3-L1 adipocyte model
[Display omitted] •Stevia-derived compounds modulate adipogenic and lipogenic gene expression.•Steviol decreases lipid accumulation in mature 3T3-L1 adipocytes.•Steviol and stevioside improve glucose uptake and mitigate insulin resistance. Stevia rebaudiana Bertoni is famous for sweetness due to the...
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| Published in: | Journal of functional foods Vol. 94; p. 105141 |
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| Format: | Journal Article |
| Language: | English |
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01-07-2022
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| Abstract | [Display omitted]
•Stevia-derived compounds modulate adipogenic and lipogenic gene expression.•Steviol decreases lipid accumulation in mature 3T3-L1 adipocytes.•Steviol and stevioside improve glucose uptake and mitigate insulin resistance.
Stevia rebaudiana Bertoni is famous for sweetness due to the content of steviol glycosides (SG). This study aimed to determine the effect of SG (stevioside, rebaudioside A) and steviol on adipogenesis and lipogenesis in the 3T3-L1 model. Test compounds were also analysed for their ability to affect glucose uptake in hypertrophied insulin-resistant 3T3-L1 adipocytes. The most active compound in modulating adipogenesis, lipogenesis and insulin resistance was steviol, SG metabolism product. Steviol (10 μM, 100 μM) significantly down-regulated the expression of adipogenic transcription factors (PPARγ, C/EBPα, SREBP1) and lipogenic genes (FAS, aP2, LPL), which caused decreased lipid accumulation and triglyceride content in adipocytes. Treatment of insulin-resistant adipocytes with steviol (1 μM) and stevioside (1 μM, 10 μM) increased GLUT-4 transcript level and improved glucose uptake. Steviol also lowered resistin gene expression, which may mitigate insulin resistance in hypertrophied adipocytes. This study promotes SG as potential health-promoting ingredients in low-calorie functional foods. |
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| AbstractList | Stevia rebaudiana Bertoni is famous for sweetness due to the content of steviol glycosides (SG). This study aimed to determine the effect of SG (stevioside, rebaudioside A) and steviol on adipogenesis and lipogenesis in the 3T3-L1 model. Test compounds were also analysed for their ability to affect glucose uptake in hypertrophied insulin-resistant 3T3-L1 adipocytes. The most active compound in modulating adipogenesis, lipogenesis and insulin resistance was steviol, SG metabolism product. Steviol (10 μM, 100 μM) significantly down-regulated the expression of adipogenic transcription factors (PPARγ, C/EBPα, SREBP1) and lipogenic genes (FAS, aP2, LPL), which caused decreased lipid accumulation and triglyceride content in adipocytes. Treatment of insulin-resistant adipocytes with steviol (1 μM) and stevioside (1 μM, 10 μM) increased GLUT-4 transcript level and improved glucose uptake. Steviol also lowered resistin gene expression, which may mitigate insulin resistance in hypertrophied adipocytes. This study promotes SG as potential health-promoting ingredients in low-calorie functional foods. [Display omitted] •Stevia-derived compounds modulate adipogenic and lipogenic gene expression.•Steviol decreases lipid accumulation in mature 3T3-L1 adipocytes.•Steviol and stevioside improve glucose uptake and mitigate insulin resistance. Stevia rebaudiana Bertoni is famous for sweetness due to the content of steviol glycosides (SG). This study aimed to determine the effect of SG (stevioside, rebaudioside A) and steviol on adipogenesis and lipogenesis in the 3T3-L1 model. Test compounds were also analysed for their ability to affect glucose uptake in hypertrophied insulin-resistant 3T3-L1 adipocytes. The most active compound in modulating adipogenesis, lipogenesis and insulin resistance was steviol, SG metabolism product. Steviol (10 μM, 100 μM) significantly down-regulated the expression of adipogenic transcription factors (PPARγ, C/EBPα, SREBP1) and lipogenic genes (FAS, aP2, LPL), which caused decreased lipid accumulation and triglyceride content in adipocytes. Treatment of insulin-resistant adipocytes with steviol (1 μM) and stevioside (1 μM, 10 μM) increased GLUT-4 transcript level and improved glucose uptake. Steviol also lowered resistin gene expression, which may mitigate insulin resistance in hypertrophied adipocytes. This study promotes SG as potential health-promoting ingredients in low-calorie functional foods. |
| ArticleNumber | 105141 |
| Author | Kowalska, Katarzyna Olejnik, Anna Krejpcio, Zbigniew Zielińska-Wasielica, Joanna Kurek, Jakub Michał |
| Author_xml | – sequence: 1 givenname: Jakub Michał surname: Kurek fullname: Kurek, Jakub Michał email: jakub.kurek@up.poznan.pl organization: Department of Human Nutrition and Dietetics, Poznań University of Life Sciences, Wojska Polskiego 31, 60-624 Poznań, Poland – sequence: 2 givenname: Joanna surname: Zielińska-Wasielica fullname: Zielińska-Wasielica, Joanna email: joanna.zielinska@up.poznan.pl organization: Department of Biotechnology and Food Microbiology, Poznań University of Life Sciences, Wojska Polskiego 48, 60-627 Poznań, Poland – sequence: 3 givenname: Katarzyna surname: Kowalska fullname: Kowalska, Katarzyna email: katarzyna.kowalska@up.poznan.pl organization: Department of Biotechnology and Food Microbiology, Poznań University of Life Sciences, Wojska Polskiego 48, 60-627 Poznań, Poland – sequence: 4 givenname: Zbigniew surname: Krejpcio fullname: Krejpcio, Zbigniew email: zbigniew.krejpcio@up.poznan.pl organization: Department of Human Nutrition and Dietetics, Poznań University of Life Sciences, Wojska Polskiego 31, 60-624 Poznań, Poland – sequence: 5 givenname: Anna surname: Olejnik fullname: Olejnik, Anna email: aolejnik@up.poznan.pl, anna.olejnik@up.poznan.pl organization: Department of Biotechnology and Food Microbiology, Poznań University of Life Sciences, Wojska Polskiego 48, 60-627 Poznań, Poland |
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| Keywords | C/EBPα aP2 RGZ Steviol DM LPL STL Insulin-resistance DMEM SG Hypertrophic adipocytes GLUT-4 FBS SREBP1 Lipogenesis Adipogenesis ST DMM IBMX Stevioside Rebaudioside A PPARγ RA TG FAS KRPH Stevia |
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10.1016/j.jff.2022.105141_b0190 article-title: Chronic consumption of rebaudioside A, a steviol glycoside, in men and women with type 2 diabetes mellitus publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2008.05.007 contributor: fullname: Maki – volume: Vol. 73 start-page: 1 year: 2016 ident: 10.1016/j.jff.2022.105141_b0095 publication-title: Chapter One—Stevia Glycosides: Chemical and Enzymatic Modifications of Their Carbohydrate Moieties to Improve the Sweet-Tasting Quality contributor: fullname: Gerwig – ident: 10.1016/j.jff.2022.105141_b0055 – volume: 3 start-page: 242 issue: 2 year: 2011 ident: 10.1016/j.jff.2022.105141_b0200 article-title: Antidiabetic activity of medium-polar extract from the leaves of Stevia rebaudiana Bert. (Bertoni) on alloxan-induced diabetic rats publication-title: Journal of Pharmacy and Bioallied Sciences doi: 10.4103/0975-7406.80779 contributor: fullname: Mehta – volume: 41 start-page: 875 issue: 6 year: 2003 ident: 10.1016/j.jff.2022.105141_b0175 article-title: Absorption and metabolism of glycosidic sweeteners of stevia mixture and their aglycone, steviol, in rats and humans publication-title: Food and Chemical Toxicology doi: 10.1016/S0278-6915(03)00039-5 contributor: fullname: Koyama |
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•Stevia-derived compounds modulate adipogenic and lipogenic gene expression.•Steviol decreases lipid accumulation in mature 3T3-L1... Stevia rebaudiana Bertoni is famous for sweetness due to the content of steviol glycosides (SG). This study aimed to determine the effect of SG (stevioside,... |
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| SubjectTerms | Adipogenesis Hypertrophic adipocytes Insulin-resistance Lipogenesis Rebaudioside A Stevia Steviol Stevioside |
| Title | Modulating effects of steviol and steviol glycosides on adipogenesis, lipogenesis, glucose uptake and insulin resistance in 3T3-L1 adipocyte model |
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