Comparison of the Genomic Profile of Cancer Stem Cells and Their Non-Stem Counterpart: The Case of Ovarian Cancer

The classical cancer stem cell (CSC) model places CSCs at the apex of a hierarchical scale, suggesting different genetic alterations in non-CSCs compared to CSCs, since an ill-defined number of cell generations and time intervals separate CSCs from the more differentiated cancer cells that form the...

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Published in:Journal of clinical medicine Vol. 9; no. 2; p. 368
Main Authors: Mazzoldi, Elena Laura, Pastò, Anna, Pilotto, Giorgia, Minuzzo, Sonia, Piga, Ilaria, Palumbo, Pietro, Carella, Massimo, Frezzini, Simona, Nicoletto, Maria Ornella, Amadori, Alberto, Indraccolo, Stefano
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 29-01-2020
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Summary:The classical cancer stem cell (CSC) model places CSCs at the apex of a hierarchical scale, suggesting different genetic alterations in non-CSCs compared to CSCs, since an ill-defined number of cell generations and time intervals separate CSCs from the more differentiated cancer cells that form the bulk of the tumor. Another model, however, poses that CSCs should be considered a functional state of tumor cells, hence sharing the same genetic alterations. Here, we review the existing literature on the genetic landscape of CSCs in various tumor types and as a case study investigate the genomic complexity of DNA obtained from matched CSCs and non-CSCs from five ovarian cancer patients, using a genome-wide single-nucleotide polymorphism (SNP) microarray.
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Current address: Department of Inflammation and Immunology, Humanitas Clinical and Research Center, Rozzano, 20089 Milan, Italy.
These authors contributed equally to this work.
Current address: Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9020368