Correlation of Clinical, Histological, and Cytokeratin Profiles of Squamous Cell Carcinoma of the Oral Tongue With Prognosis

• Published in: International journal of surgical pathology Vol. 15; no. 4; pp. 376 - 383
• Main Authors: Dantas da Silveira, Ericka Janine, Pina Godoy, Gustavo, AlvesUchôa Lins, Ruthinéia Diógenes, Silva Arruda, Maria de Lourdes, Formiga Ramos, Carlos Cesar, de Almeida Freitas, Roseana, Guedes Queiroz, Lélia Maria
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01-10-2007
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - metabolism; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - therapy; Combined Modality Therapy; Disease-Free Survival; Female; Humans; Immunohistochemistry - methods; Keratins - metabolism; Male; Middle Aged; Remission Induction; Retrospective Studies; Survival Rate; Tongue Neoplasms - metabolism; Tongue Neoplasms - mortality; Tongue Neoplasms - pathology; Tongue Neoplasms - therapy; metastases; histological grading; immunohistochemistry; TNM classification; tongue squamous cell carcinoma
• ISSN: 1066-8969; 1940-2465
• DOI: 10.1177/1066896907304992

The aim of the present study was to clinically, morphologically, and immunohistochemically correlate the expression of cytokeratins (CKs) 7, 10, 13, 14, 16, and 19 in 30 cases of tongue squamous cell carcinoma (SCC) with disease outcome, metastases, clinical stage (tumor, node, metastasis [TNM]), and histological grade of malignancy proposed by Bryne. Statistical analysis (χ2 test) showed that only histological grading was not significantly correlated with the clinical variables. CK expression varied in the samples analyzed. CK 10 expression was significantly correlated with the presence of metastases, and the expression of CK 16 was related to disease outcome and also to TNM stages III and IV. These results indicate that metastases and TNM are effective prognostic indicators. The histological grading proposed by Bryne did not reflect the biological behavior of the tongue SCC cases studied. Analysis of some intermediate CK filaments can reflect the biological behavior and aggressiveness of some tongue SCCs.