Ontogeny of Small Intestinal Drug Transporters and Metabolizing Enzymes Based on Targeted Quantitative Proteomics

Most drugs are administered to children orally. An information gap remains on the protein abundance of small intestinal drug-metabolizing enzymes (DMEs) and drug transporters (DTs) across the pediatric age range, which hinders precision dosing in children. To explore age-related differences in DMEs...

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Bibliographic Details
Published in:	Drug metabolism and disposition Vol. 49; no. 12; pp. 1038 - 1046
Main Authors:	Kiss, Márton, Mbasu, Richard, Nicolaï, Johan, Barnouin, Karin, Kotian, Apoorva, Mooij, Miriam G, Kist, Nico, Wijnen, Rene M H, Ungell, Anna-Lena, Cutler, Paul, Russel, Frans G M, de Wildt, Saskia N
Format:	Journal Article
Language:	English
Published:	United States 01-12-2021
Subjects:	Adult Age Factors ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism Biological Transport, Active Child Chromatography, Liquid - methods Cytochrome P-450 CYP3A - metabolism Enzyme Assays - methods Gene Ontology Glucuronosyltransferase - metabolism Humans Inactivation, Metabolic - physiology Intestine, Small - drug effects Intestine, Small - enzymology Intestine, Small - metabolism Membrane Transport Proteins - metabolism Metabolic Clearance Rate Multidrug Resistance-Associated Protein 2 - metabolism Neoplasm Proteins - metabolism Peptide Transporter 1 - metabolism Tandem Mass Spectrometry - methods
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