Experimental benznidazole encephalopathy: II. Electroencephalographic and morphological alterations

We describe electroencephalographic (EEG) and morphological alterations in the CNS of dogs treated with benznidazole. The relationship between dose, duration of treatment and intensity of lesions observed was examined and used to establish anatomo-clinical associations. Two predominant EEG patterns...

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Bibliographic Details
Published in:	Journal of the neurological sciences Vol. 150; no. 1; pp. 13 - 25
Main Authors:	Flores-Vieira, Carmen Lucia Leite, Chimelli, Leila, Maria França Fernandes, Regina, Antunes Barreira, Amilton
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier B.V 01-09-1997 Elsevier Science
Subjects:	Animals Benznidazole Biological and medical sciences Brain - drug effects Brain - pathology Brain Diseases - chemically induced Brain Diseases - pathology Brain Diseases - physiopathology Cerebellum - drug effects Cerebellum - pathology Chagas' disease Dogs Drug toxicity and drugs side effects treatment Electroencephalographic and morphological alterations Electroencephalography - drug effects Experimental encephalopathy Medical sciences Microglia - drug effects Microglia - pathology Nerve Degeneration Neurons - drug effects Neurons - pathology Neurotoxins Nitroimidazoles - toxicity Peripheral Nerves - drug effects Peripheral Nerves - pathology Pharmacology. Drug treatments Reference Values Toxicity: nervous system and muscle Tropical medicine Trypanocidal Agents - toxicity Benznidazole Chagas' disease Electroencephalographic and morphological alterations Experimental encephalopathy Fissipedia Nitro compound Imidazole derivatives Carnivora Nervous system diseases Toxicity Male Processing time Electroencephalography Cerebral disorder Electrodiagnosis Pathology Antiprotozoal agent Vertebrata Mammalia Treatment Encephalopathy Central nervous system disease Adult animal Parasiticid Dog
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