Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine

The synthesis and in vitro evaluation of the acetamidine derivatives of hetero-substituted lysine and homolysine analogues have identified potent inhibitors of human nitric oxide synthase enzymes, including examples with marked selectivity for the inducible isoform.

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Published in:Bioorganic & medicinal chemistry letters Vol. 10; no. 6; pp. 597 - 600
Main Authors: YOUNG, R. J, BEAMS, R. M, FRENCH, C, HODGSON, S. T, HODSON, H. F, KLEANTHOUS, S, RIDER, P, SANDERS, D, SAWYER, D. A, SCOTT, K. J, SHEARER, B. G, STOCKER, R, CARTER, K, SMITH, S, TACKLEY, M. C, KNOWLES, R. G, CLARK, H. A. R, COE, D. M, CHAMBERS, C. L, DAVIES, P. I, DAWSON, J, DRYSDALE, M. J, FRANZMAN, K. W
Format: Journal Article
Language:English
Published: Oxford Elsevier 20-03-2000
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Abstract The synthesis and in vitro evaluation of the acetamidine derivatives of hetero-substituted lysine and homolysine analogues have identified potent inhibitors of human nitric oxide synthase enzymes, including examples with marked selectivity for the inducible isoform.
AbstractList The synthesis and in vitro evaluation of the acetamidine derivatives of hetero-substituted lysine and homolysine analogues have identified potent inhibitors of human nitric oxide synthase enzymes, including examples with marked selectivity for the inducible isoform.
Author RIDER, P
TACKLEY, M. C
FRENCH, C
SCOTT, K. J
SMITH, S
CHAMBERS, C. L
DAWSON, J
YOUNG, R. J
STOCKER, R
HODSON, H. F
SAWYER, D. A
CLARK, H. A. R
COE, D. M
HODGSON, S. T
DRYSDALE, M. J
SANDERS, D
CARTER, K
KNOWLES, R. G
SHEARER, B. G
FRANZMAN, K. W
KLEANTHOUS, S
DAVIES, P. I
BEAMS, R. M
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Issue 6
Keywords Human
Ether
Sulfone
Enzyme
Isozyme
Enzyme inhibitor
Selectivity
In vitro
Nitric-oxide synthase
Organic sulfide
Sulfur containing aminoacid
α-Aminoacid
Amidine
Structure activity relation
Sulfoxide
Oxidoreductases
Chemical synthesis
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Snippet The synthesis and in vitro evaluation of the acetamidine derivatives of hetero-substituted lysine and homolysine analogues have identified potent inhibitors of...
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SubjectTerms Acetamides - chemical synthesis
Acetamides - pharmacology
Biological and medical sciences
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - pharmacology
Humans
Indicators and Reagents
Isoenzymes - antagonists & inhibitors
Lysine - analogs & derivatives
Lysine - chemical synthesis
Lysine - pharmacology
Medical sciences
Miscellaneous
Nitric Oxide Synthase - antagonists & inhibitors
Nitric Oxide Synthase Type II
Ornithine - analogs & derivatives
Ornithine - pharmacology
Pharmacology. Drug treatments
Sulfides - pharmacology
Sulfones - pharmacology
Title Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine
URI https://www.ncbi.nlm.nih.gov/pubmed/10741561
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