Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine
The synthesis and in vitro evaluation of the acetamidine derivatives of hetero-substituted lysine and homolysine analogues have identified potent inhibitors of human nitric oxide synthase enzymes, including examples with marked selectivity for the inducible isoform.
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Published in: | Bioorganic & medicinal chemistry letters Vol. 10; no. 6; pp. 597 - 600 |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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20-03-2000
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Abstract | The synthesis and in vitro evaluation of the acetamidine derivatives of hetero-substituted lysine and homolysine analogues have identified potent inhibitors of human nitric oxide synthase enzymes, including examples with marked selectivity for the inducible isoform. |
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AbstractList | The synthesis and in vitro evaluation of the acetamidine derivatives of hetero-substituted lysine and homolysine analogues have identified potent inhibitors of human nitric oxide synthase enzymes, including examples with marked selectivity for the inducible isoform. |
Author | RIDER, P TACKLEY, M. C FRENCH, C SCOTT, K. J SMITH, S CHAMBERS, C. L DAWSON, J YOUNG, R. J STOCKER, R HODSON, H. F SAWYER, D. A CLARK, H. A. R COE, D. M HODGSON, S. T DRYSDALE, M. J SANDERS, D CARTER, K KNOWLES, R. G SHEARER, B. G FRANZMAN, K. W KLEANTHOUS, S DAVIES, P. I BEAMS, R. M |
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Cites_doi | 10.1016/S0968-0896(99)00029-2 10.1002/(SICI)1521-3773(19990614)38:12<1714::AID-ANIE1714>3.0.CO;2-3 10.1385/1-59259-749-1:237 10.1074/jbc.274.30.21276 10.1517/13543784.7.1.65 10.1016/S0040-4039(96)02268-X 10.1111/j.1476-5381.1990.tb14151.x 10.1038/6675 10.1016/0040-4039(96)00676-4 10.1073/pnas.86.13.5159 10.1248/cpb.43.1137 10.1016/S0076-6879(96)68047-1 10.1038/327524a0 |
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SubjectTerms | Acetamides - chemical synthesis Acetamides - pharmacology Biological and medical sciences Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - pharmacology Humans Indicators and Reagents Isoenzymes - antagonists & inhibitors Lysine - analogs & derivatives Lysine - chemical synthesis Lysine - pharmacology Medical sciences Miscellaneous Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase Type II Ornithine - analogs & derivatives Ornithine - pharmacology Pharmacology. Drug treatments Sulfides - pharmacology Sulfones - pharmacology |
Title | Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine |
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